Product Description |
Recombinant Human B2M/beta 2-Microglobulin Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Ile21-Met119. |
Product Background |
The genetic and functional analysis of β2-microglobulin (B2M), a component of the HLA class-I complex.Acquired homozygous loss of B2M that caused lack of cell-surface HLA Class I expression in the tumor and a matched patient-derived xenograft (PDX). Downregulation of B2M was also found in two additional PDXs established from ICI-resistant tumors. |
Product Category |
Recombinant Protein |
Target |
B2M/beta 2-Microglobulin |
Synonyms |
Beta-2-microglobulin；B2M |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Ile21-Met119 |
Molecular Weight |
The protein has a predicted MW of 12.8 kDa. Due to glycosylation, the protein migrates to 13-15 kDa based on Bis-Tris PAGE result. |
Product Tag |
C-His |
Express System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
|
|
Human B2M on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
|
The purity of Human B2M is greater than 95% as determined by SEC-HPLC. |
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