Human BACE-1 Protein (BAE-HM201)
Human BACE-1 Protein (BAE-HM201)
  • Express System: HEK293
  • Product Tag: C-hFc
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Amino Acid Range: Thr22-Thr457
Catalog #BAE-HM201
Regular price $148.50
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Product Description

Recombinant Human BACE-1 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Thr22-Thr457.

Product Background

The beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1) initiates the generation of amyloid-β (Aβ), and the amyloid cascade leading to amyloid plaque deposition, neurodegeneration, and dementia in Alzheimer's disease (AD). Clinical failures of anti-Aβ therapies in dementia stages suggest that treatment has to start in the early, asymptomatic disease states.

Product Category

Recombinant Protein / Antibody discovery / Antibody discovery | Others

Protein

BACE-1

Synonyms

Beta-secretase 1; ASP2; Asp 2; BACE1; BACE; FLJ90568; HSPC104; KIAA1149; Memapsin-2; BACE-1; EC 3.4.23; EC 3.4.23.46;β-secretase 1

Accession

Species

Human

Biotinylated

no

Amino Acid Range

Thr22-Thr457

Molecular Weight

The protein has a predicted MW of 75.2 kDa (pro-form) and 72.6 kDa (mature-form). Due to glycosylation, the protein migrates to 85-100 kDa based on Bis-Tris PAGE result.

Product Tag

C-hFc

Expression System

HEK293

Purity

> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC

Endotoxin

Less than 1 EU per ug by the LAL method.
Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage
-20 to -80°C for 12 months as supplied from date of receipt.;-80°C for 3 months after reconstitution.;Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Human BACE-1 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. Human BACE-1 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human BACE-1 is greater than 95% as determined by SEC-HPLC. The purity of Human BACE-1 is greater than 95% as determined by SEC-HPLC.

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Contact Us

support@kactusbio.us

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