Name: Human BDCA-2 Protein (BCA-HM302)
Brand: KactusBio
SKU: BCA-HM302-100UG
Price: 346.5 USD
Availability: InStock

Express System: HEK293
Product Tag: N-mFc
Purity: > 95% as determined by Bis-Tris PAGE
Activity: Immobilized Human BDCA-2, mFc Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-BDCA-2 Antibody, hFc Tag with the EC50 of 5.7ng/ml determined by ELISA. See testing image for detail.
Amino Acid Range: Phe46-Ile213

Catalog #BCA-HM302

Size

100UG

500UG

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Product Description	Recombinant Human BDCA-2 Protein is expressed from HEK293 with mFc (IgG2a) tag at the N-Terminus.It contains Phe46-Ile213.
Product Background	BDCA-2 is a novel type II C-type lectin specifically expressed by plasmacytoid dendritic cells (PDCs) that can internalize antigen for presentation to T cells. Furthermore, signaling via BDCA-2 may play a role in switching from interferon (IFN)-α/β-controlled to interleukin (IL)-12-controlled immune response pathways, as triggering of BDCA-2 potently inhibits secretion of IFN-α/β by PDCs and thereby promotes IL-12 p70 production in PDCs and other cells.
Product Category	Recombinant Protein / Antibody discovery

Protein	BDCA-2
Synonyms	BDCA-2; BDCA2; CLECSF11; CLECSF7; DLEC; HECL; CLEC4C; CD303;
Accession	Q8WTT0-1
Species	Human
Biotinylated	no
Amino Acid Range	Phe46-Ile213
Molecular Weight	The protein has a predicted MW of 46.39 kDa. Due to glycosylation, the protein migrates to 55-65 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Human BDCA-2, mFc Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-BDCA-2 Antibody, hFc Tag with the EC50 of 5.7ng/ml determined by ELISA. See testing image for detail.
Product Tag	N-mFc
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in 20mM Tris, 150mM NaCl, 200mM L-arginine (pH 8.5). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Human BDCA-2, mFc Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-BDCA-2 Antibody, hFc Tag with the EC50 of 5.7ng/ml determined by ELISA.
	Human BDCA-2 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.