Name: Human c-MPL/Thrombopoietin R Protein (MPL-HM101)
Brand: KactusBio
SKU: MPL-HM101-100UG
Price: 345.0 USD
Availability: InStock

Human c-MPL/Thrombopoietin R Protein (MPL-HM101)

Human c-MPL, His Tag immobilized on CM5 Chip can bind Human Thrombopoietin, His Tag with an affinity constant of 25.54 nM as determined in SPR assay (Biacore T200).

Immobilized Human c-MPL, His Tag at 0.5ug/ml (100ul/Well) on the plate. Dose response curve for Anti-c-MPL Antibody, hFc Tag with the EC50 of 3.4ng/ml determined by ELISA (QC Test).

Human c-MPL on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

The purity of Human c-MPL is greater than 95% as determined by SEC-HPLC.

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Human c-MPL, His Tag at 0.5ug/ml (100ul/Well) on the plate. Dose response curve for Anti-c-MPL Antibody, hFc Tag with the EC50 of 3.4ng/ml determined by ELISA (QC Test). The affinity constant of 25.54 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Amino Acid Range: Gln26-Trp491

Catalog #MPL-HM101

Size

100UG

500UG

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Product Description	Recombinant Human c-MPL/Thrombopoietin R Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gln26-Trp491.
Product Background	The c-mpl gene encodes a member of the hematopoietic cytokine receptor superfamily. This gene was discovered through the study of a murine retrovirus which induces an acute myeloproliferative syndrome in mice.MPLV (for myeloproliferative leukemia virus) has transduced a truncated and constitutively activated form of the c-mpl receptor chain. High levels of c-mpl expression were detected in 45% of acute myeloid leukemia (AML). No correlation was found between c-mpl expression and the French-American-British classification subtype of AML.
Product Category	Recombinant Protein / Antibody discovery

Protein	c-MPL/Thrombopoietin R
Synonyms	TPO-R; CD110; MPL; c-Mpl; MPLV; K12
Accession	P40238-1
Species	Human
Biotinylated	no
Amino Acid Range	Gln26-Trp491
Molecular Weight	The protein has a predicted MW of 53.6 kDa. Due to glycosylation, the protein migrates to 67-77 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Human c-MPL, His Tag at 0.5ug/ml (100ul/Well) on the plate. Dose response curve for Anti-c-MPL Antibody, hFc Tag with the EC50 of 3.4ng/ml determined by ELISA (QC Test). The affinity constant of 25.54 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag	C-His
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 0.1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Human c-MPL, His Tag immobilized on CM5 Chip can bind Human Thrombopoietin, His Tag with an affinity constant of 25.54 nM as determined in SPR assay (Biacore T200).
	Immobilized Human c-MPL, His Tag at 0.5ug/ml (100ul/Well) on the plate. Dose response curve for Anti-c-MPL Antibody, hFc Tag with the EC50 of 3.4ng/ml determined by ELISA (QC Test).
	Human c-MPL on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Human c-MPL is greater than 95% as determined by SEC-HPLC.