Name: Human c-MPL/Thrombopoietin R Protein (MPL-HM101)
Brand: KactusBio
SKU: MPL-HM101-100UG
Price: 379.5 USD
Availability: InStock

Human c-MPL/Thrombopoietin R Protein (MPL-HM101)

Human c-MPL, His Tag immobilized on CM5 Chip can bind Human Thrombopoietin, His Tag with an affinity constant of 25.54 nM as determined in SPR assay (Biacore T200).

Immobilized Human c-MPL, His Tag at 0.5ug/ml (100ul/Well) on the plate. Dose response curve for Anti-c-MPL Antibody, hFc Tag with the EC50 of 3.4ng/ml determined by ELISA (QC Test).

Human c-MPL on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

The purity of Human c-MPL is greater than 95% as determined by SEC-HPLC.

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Human c-MPL, His Tag at 0.5ug/ml (100ul/Well) on the plate. Dose response curve for Anti-c-MPL Antibody, hFc Tag with the EC50 of 3.4ng/ml determined by ELISA (QC Test). The affinity constant of 25.54 nM as determined in SPR assay (Biacore T200).
Amino Acid Range: Gln26-Trp491
Other Available Proteins:

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Catalog #MPL-HM101

Size

100UG

500UG

Order by 4pm ET for delivery on:

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Human c-MPL/Thrombopoietin R Protein (MPL-HM101) Summary

Product Description	Recombinant Human c-MPL/Thrombopoietin R Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gln26-Trp491.
Product Background	The c-mpl gene encodes a member of the hematopoietic cytokine receptor superfamily. This gene was discovered through the study of a murine retrovirus which induces an acute myeloproliferative syndrome in mice.MPLV (for myeloproliferative leukemia virus) has transduced a truncated and constitutively activated form of the c-mpl receptor chain. High levels of c-mpl expression were detected in 45% of acute myeloid leukemia (AML). No correlation was found between c-mpl expression and the French-American-British classification subtype of AML.
Product Category	Recombinant Protein / Antibody discovery / Antibody discovery \| Others

Human c-MPL/Thrombopoietin R Protein (MPL-HM101) Specifications/Details

Protein	c-MPL/Thrombopoietin R
Synonyms	TPO-R; CD110; MPL; c-Mpl; MPLV; K12
Accession	P40238-1
Species	Human
Biotinylated	no
Amino Acid Range	Gln26-Trp491
Molecular Weight	The protein has a predicted MW of 53.6 kDa. Due to glycosylation, the protein migrates to 67-77 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Human c-MPL, His Tag at 0.5ug/ml (100ul/Well) on the plate. Dose response curve for Anti-c-MPL Antibody, hFc Tag with the EC50 of 3.4ng/ml determined by ELISA (QC Test). The affinity constant of 25.54 nM as determined in SPR assay (Biacore T200).
Product Tag	C-His
Fluorophore	Unconjugated
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

	Human c-MPL, His Tag immobilized on CM5 Chip can bind Human Thrombopoietin, His Tag with an affinity constant of 25.54 nM as determined in SPR assay (Biacore T200).
	Immobilized Human c-MPL, His Tag at 0.5ug/ml (100ul/Well) on the plate. Dose response curve for Anti-c-MPL Antibody, hFc Tag with the EC50 of 3.4ng/ml determined by ELISA (QC Test).
	Human c-MPL on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Human c-MPL is greater than 95% as determined by SEC-HPLC.

Human c-MPL/Thrombopoietin R Protein (MPL-HM101) Summary

Product Description

Product Background

Product Category

Human c-MPL/Thrombopoietin R Protein (MPL-HM101) Specifications/Details

Fluorophore

Shipping, Reconstitution, & Storage

Validation Images

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