Human c-MPL/Thrombopoietin R Protein (MPL-HM101)
Catalog: MPL-HM101
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| Product Description | Recombinant Human c-MPL/Thrombopoietin R Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gln26-Trp491. |
Product Background |
The c-mpl gene encodes a member of the hematopoietic cytokine receptor superfamily. This gene was discovered through the study of a murine retrovirus which induces an acute myeloproliferative syndrome in mice.MPLV (for myeloproliferative leukemia virus) has transduced a truncated and constitutively activated form of the c-mpl receptor chain. High levels of c-mpl expression were detected in 45% of acute myeloid leukemia (AML). No correlation was found between c-mpl expression and the French-American-British classification subtype of AML. |
Product Category |
Recombinant Protein |
Target |
c-MPL/Thrombopoietin R |
| Synonyms | TPO-R; CD110; MPL; c-Mpl; MPLV; K12 |
Gene/Protein ID |
P40238-1 |
Species |
Human |
Exact Sequence |
Gln26-Trp491 |
| Molecular Weight | The protein has a predicted MW of 53.6 kDa. Due to glycosylation, the protein migrates to 68-70 kDa based on Tris-Bis PAGE result. |
Activity |
Immobilized Human c-MPL, His Tag at 0.2ug/ml (100ul/Well) on the plate. Dose response curve for Anti-c-MPL Antibody, hFc Tag with the EC50 of 9.1ng/ml determined by ELISA. See testing image for detail. |
Product Tag |
C-His |
Express System |
HEK293 |
| Purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
| Endotoxin | Less than 1EU per ug by the LAL method. |
| Form | Lyophilized |
| Shipping | Shipped at ambient temperature. |
| Formulation | Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| Stability And Storage | Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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Immobilized Human c-MPL, His Tag at 0.2ug/ml (100ul/Well) on the plate. Dose response curve for Anti-c-MPL Antibody, hFc Tag with the EC50 of 9.1ng/ml determined by ELISA. |
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The purity of Human c-MPL is greater than 95% as determined by SEC-HPLC. |
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Human c-MPL on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
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