Product Description |
Recombinant Human CADM1/IGSF4A Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gln45-His374. |
Product Background |
The cell adhesion molecule 1 (CADM1) is a molecule of cell adhesion with multiple functions and has been identified as a tumor suppressor gene. CADM1 has multifunctions on the pathogenesis of malignancies, and other normal cells such as immune cells. On the contrary to these cutaneous solid tumors except for Merkel cell carcinoma, cutaneous lymphomas, such as adult-T cell leukemia/lymphoma, mycosis fungoides, and Sézary syndrome, increase their CADM1 expression for the development of tumor environment. |
Product Category |
Recombinant Protein / Antibody discovery / Antibody discovery | Others |
Protein |
CADM1/IGSF4A |
Synonyms |
IgSF4; NECL-2; SgIgSF; SynCAM; TSLC-1; Cadm1; BL2; IGSF4; IGSF4A; RA175; ST17; TSLC1; sTSLC-1; sgIGSF; synCAM1; BL2; NECL2 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Gln45-His374 |
Molecular Weight |
The protein has a predicted MW of 38 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Human CADM1, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-CADM1 Antibody, hFc Tag with the EC50 of 4.0g/ml determined by ELISA. See testing image for detail. |
Product Tag |
C-His |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
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Immobilized Human CADM1, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-CADM1 Antibody, hFc Tag with the EC50 of 4.0g/ml determined by ELISA. |
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Human CADM1 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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The purity of Human CADM1 is greater than 95% as determined by SEC-HPLC. |
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