Product Description |
Recombinant Human CADM3 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Asn25-Tyr329. |
Product Background |
Cell adhesion molecules belonging to the Cadm family, and in particular Cadm3 (axonal) and its heterophilic binding partner Cadm4 (Schwann cell), mediate these interactions along the internode.over-expressing Cadm3 on the surface of DRG neuron axons results in an almost complete inability by Schwann cells to form myelin segments. Axons of superior cervical ganglion (SCG) neurons, which do not normally support the formation of myelin segments by Schwann cells, express higher levels of Cadm3 compared to DRG neurons. |
Product Category |
Recombinant Protein / Antibody discovery |
Protein |
CADM3 |
Synonyms |
IgSF4B; NECL-1; SynCAM3; GSF4B; NECL1; TSLL1; CADM3; BIgR; IGSF4B; member 4B; TSLC1-like 1 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Asn25-Tyr329 |
Molecular Weight |
The protein has a predicted MW of 34.6 kDa. Due to glycosylation, the protein migrates to 38-45 kDa based on Bis-Tris PAGE result. |
Product Tag |
C-His |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
|
|
Human CADM3 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
|
The purity of Human CADM3 is greater than 95% as determined by SEC-HPLC. |
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