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Human Cathepsin C/DPPI Protein (DPP-HM101) Summary
Product Description |
Recombinant Human Cathepsin C/DPPI Protein is expressed from HEK293 with His tag at the C-terminus.It contains Asp25-Leu463. |
Product Background |
Cathepsin C (CTSC) is a lysosomal cysteine protease constitutively expressed at high levels in the lung, kidney, liver, and spleen. It plays a key role in the activation of serine proteases in cytotoxic T cells, natural killer cells (granzymes A and B), mast cells (chymase and tryptase) and neutrophils (cathepsin G, neutrophil elastase, proteinase 3) underscoring its pivotal significance in immune and inflammatory defenses. |
Product Category |
Recombinant Protein / Antibody discovery / Antibody discovery/Others |
Human Cathepsin C/DPPI Protein (DPP-HM101) Specifications/Details
Protein |
Cathepsin C/DPPI |
Synonyms |
Cathepsin C; Cathepsin J; Dipeptidyl peptidase 1; CTSC; Dipeptidyl transferase |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Asp25-Leu463 |
Molecular Weight |
The protein has a predicted MW of 51.17 kDa. Due to glycosylation, the protein migrates to 55-65 kDa based on Bis-Tris PAGE result. |
Activity |
Measured by its ability to cleave the fluorogenic peptide substrate, Gly-Arg-7-amido-4-methylcoumarin (GR-AMC). The specific activity is >30000 pmol/min/µg. |
Product Tag |
C-His |
Fluorophore |
Unconjugated |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 0.1 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22 um filtered solution in 50mM MES, 150mM NaCl, 20% glycerol (pH 6.0). |
Stability And Storage |
Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
|
|
Human Cathepsin C on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
|
The purity of Human Cathepsin C is greater than 95% as determined by SEC-HPLC. |
Other Available Proteins:
Finding available proteins...
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