Product Description |
Recombinant FITC-equivalent Human CCR7 Protein-Nanodisc is expressed from HEK293 with His tag at the C-terminus.It contains Met1-Pro378. |
Product Background |
CC-chemokine receptor 7 (CCR7), collaborated with its ligands CCL19 and CCL21, controls extensive migratory events in the immune system. CCR7-bearing dendritic cells can swarm into T-cell zones in lymph nodes, initiating the antigen presentation and T-cell response. Abnormal expression of CCR7 in dendritic cells will cause a series of inflammatory diseases due to the chaotic dendritic cell trafficking. |
Product Category |
Recombinant Protein |
Target |
CCR7 |
Synonyms |
CCR7; C-C CKR-7; CC-CKR-7; CCR-7; BLR2; CDw197; EBI1; CD197; CMKBR7; EBI1; EVI1 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Met1-Pro378 |
Molecular Weight |
The protein has a predicted MW of 67.70 kDa. |
Activity |
Immobilized FITC-equivalent Human CCR7 Nanodisc, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-CCR7 Antibody, hFc Tag with the EC50 of 0.21ug/ml determined by ELISA (QC Test). The affinity constant of 4.11 nM as determined in SPR assay (Biacore T200). See testing image for detail. |
Product Tag |
C-His |
Fluorophore |
FITC |
Express System |
HEK293 |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22 um filtered solution in PBS (pH 7.4). |
Stability And Storage |
Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
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FITC-equivalent Human CCR7 Nanodisc, His Tag captured on CM5 Chip via Anti-his antibody can bind Anti-CCR7 Antibody, hFc Tag with an affinity constant of 4.11 nM as determined in SPR assay (Biacore T200). |
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|
Immobilized FITC-equivalent Human CCR7 Nanodisc, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-CCR7 Antibody, hFc Tag with the EC50 of 0.21ug/ml determined by ELISA (QC Test). |
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