Human CD46 (Sushi Domain2-4) Protein (CD4-HM1D1)

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Amino Acid Range: Glu97-Arg285

Catalog #CD4-HM1D1

Price

$390⁰⁰

Size

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Human CD46 (Sushi Domain2-4) Protein (CD4-HM1D1) Summary

Product Description

Recombinant Human CD46 (Sushi Domain2-4) Protein is expressed from HEK293 with His tag at the C-terminus.It contains Glu97-Lys285.

Product Background

CD46 was discovered in 1986 during a search for novel C3b-binding proteins. CD46 is expressed ubiquitously and functions as a co-factor in the factor I-mediated proteolytic cleavage of C3b and C4b. Its vital role in preventing complement deposition on host tissue is underpinned by the fact that deficiency of CD46 is a predisposing factor for numerous disease conditions arising from complement-mediated 'self-attack'.

Human CD46 (Sushi Domain2-4) Protein (CD4-HM1D1) Specifications/Details

Protein	CD46
Synonyms	TLX; CD46; MCP; MIC10; AHUS2; TRA2.10
Accession	P15529-1
Species	Human
Biotinylated	no
Amino Acid Range	Glu97-Arg285
Molecular Weight	The protein has a predicted MW of 22.66 kDa. Due to glycosylation, the protein migrates to 28-40 kDa based on Bis-Tris PAGE result.
Product Tag	C-His
Fluorophore	Unconjugated
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 0.1 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form	Liquid
Shipping	Shipped with dry ice.
Formulation	Supplied as 0.22 um filtered solution in PBS (pH 7.4).
Stability And Storage	Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

	Human CD46 (Sushi Domain2-4) on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Human CD46 (Sushi Domain2-4) is greater than 95% as determined by SEC-HPLC.