Name: Human CD8 alpha&beta Heterodimer Protein, Ultra Low Endotoxin (CD8-HM1AB-UL)
Brand: KactusBio
SKU: CD8-HM1AB-UL-100UG
Price: 417.0 USD
Availability: InStock

Human CD8 alpha&beta Heterodimer Protein, Ultra Low Endotoxin (CD8-HM1AB-UL)

Immobilized Human CD8A&CD8B, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Anti-CD8 Antibody, hFc Tag with the EC50 of 11.3ng/ml determined by ELISA (QC Test).

Human CD8 alpha&beta Heterodimer on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

The purity of Human CD8 alpha&beta Heterodimer is greater than 95% as determined by SEC-HPLC.

Express System: HEK293
Product Tag: C-His-Flag
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Human CD8A&CD8B, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Anti-CD8 Antibody, hFc Tag with the EC50 of 11.3ng/ml determined by ELISA (QC Test). See testing image for detail.
Amino Acid Range: Ser22-Asp182(CD8 alpha) acidic tail & Leu22-Pro170(CD8 beta) basic tail

Catalog #CD8-HM1AB-UL

Size

100UG

500UG

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Product Description	Recombinant Human CD8 alpha&beta Heterodimer Protein is expressed from HEK293 with His tag at the C-Terminus of CD8 alpha and Flag tag at the C-Terminus of CD8 beta.It contains Ser22-Asp182(CD8 alpha) acidic tail and Leu22-Pro170(CD8 beta) basic tail.
Product Background	CD8 alpha&beta (CD8αβ) is a heterodimeric form of CD8. CD8α is required for surface expression of CD8β. The extracellular IgV-like domain of CD8α interacts with the α3 portion of the class I MHC molecule. CD8αβ is expressed on human peripheral T cells and functions as a coreceptor and can greatly increase the sensitivity and breadth of antigen recognition by CD8⁺ peripheral T cells bearing TCR.
Product Category	Recombinant Protein / Antibody discovery / Antibody discovery \| Others

Protein	CD8 alpha&beta
Synonyms	CD8 alphaβ CD8A&CD8B;
Accession	P01732-1(CD8 alpha)&P10966-1(CD8 beta)
Species	Human
Biotinylated	no
Amino Acid Range	Ser22-Asp182(CD8 alpha) acidic tail & Leu22-Pro170(CD8 beta) basic tail
Molecular Weight	The protein has a predicted MW of 23.54 kDa (CD8 alpha) and 22.62 kDa (CD8 beta). Due to glycosylation, the protein migrates to 30-45 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Human CD8A&CD8B, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Anti-CD8 Antibody, hFc Tag with the EC50 of 11.3ng/ml determined by ELISA (QC Test). See testing image for detail.
Product Tag	C-His-Flag
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 0.01 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Human CD8A&CD8B, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Anti-CD8 Antibody, hFc Tag with the EC50 of 11.3ng/ml determined by ELISA (QC Test).
	Human CD8 alpha&beta Heterodimer on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Human CD8 alpha&beta Heterodimer is greater than 95% as determined by SEC-HPLC.