Product Description |
Recombinant Human CD93/C1q R1 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Thr22-Lys580. |
Product Background |
CD93 has been shown critical roles in inflammatory and immune diseases. CD93 silencing increased IL-6 and TSLP, but not IL-33 levels in culture supernatants. HDM-induced asthma mice showed significant airway hyperresponsiveness and inflammation with Th2 cytokine activation, along with decreased CD93 expression in bronchial epithelial cells and lung homogenates but increased serum CD93 levels. |
Product Category |
Recombinant Protein |
Target |
CD93/C1q R1 |
Synonyms |
C1q/MBL/SPA receptor; C1qR; C1qR(p); C1qRp; CDw93; CD93; C1QR1; MXRA4; ECSM3; dJ737E23.1 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Thr22-Lys580 |
Molecular Weight |
The protein has a predicted MW of 59.4 kDa. Due to glycosylation, the protein migrates to 95-110 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Human CD93, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human IGFBP-7, hFc Tag with the EC50 of 0.69ug/ml determined by ELISA (QC Test). See testing image for detail. |
Product Tag |
C-His |
Express System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
|
|
Immobilized Human CD93, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human IGFBP-7, hFc Tag with the EC50 of 0.69ug/ml determined by ELISA (QC Test). |
|
|
Human CD93 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
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The purity of Human CD93 is greater than 95% as determined by SEC-HPLC. |
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