Human CD96/TACTILE (C110S) Protein (CD9-HM19S)

  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Activity: The affinity constant of 0.289 uM as determined in SPR assay (Biacore T200). See testing image for detail.
  • Exact Sequence: Val22-Met503(C110S)

Catalog: CD9-HM19S

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Product Description Recombinant Human CD96/TACTILE (C110S) Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Val22-Met503(C110S).

Product Background

The receptors CD96 and TIGIT are expressed on the surface of T and natural killer (NK) cells, and recent studies suggest both play important inhibitory roles in immune function. CD96 has been shown to modulate immune cell activity in mice, with Cd96-/- mice displaying hypersensitive NK-cell responses to immune challenge and significant tumor resistance. The counterbalance between the putative inhibitory CD96 and TIGIT receptors and the activating receptor, CD226, offers unique strategies for immuno-oncology drug development.

Product Category

Recombinant Protein

Target

CD96/TACTILE (C110S)

Gene/Protein ID

P40200-2

Species

Human

Exact Sequence

Val22-Met503(C110S)
Molecular Weight The protein has a predicted MW of 54.63 kDa. Due to glycosylation, the protein migrates to 100-130 kDa based on Tris-Bis PAGE result.

Activity

The affinity constant of 0.289 uM as determined in SPR assay (Biacore T200). See testing image for detail.

Product Tag

C-His

Express System

HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Human CD155, hFc Tag captured on CM5 Chip via Protein A can bind Human CD96 (C110S) , His Tag with an affinity constant of 0.289 uM as determined in SPR assay (Biacore T200).
The purity of Human CD96 (C110S) is greater than 95% as determined by SEC-HPLC.
Human CD96 (C110S) on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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