Name: Human CD96/TACTILE Protein (CD9-HM196)
Brand: KactusBio
SKU: CD9-HM196-100UG
Price: 379.5 USD
Availability: InStock

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Bis-Tris PAGE
Activity: Immobilized Anti-CD96 Antibody, hFc Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Human CD96, His Tag with the EC50 of 28.8ng/ml determined by ELISA (QC Test). The affinity constant of 0.958 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Amino Acid Range: Val22-Met503

Catalog #CD9-HM196

Size

100UG

500UG

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Product Description	Recombinant Human CD96/TACTILE Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Val22-Met503.
Product Background	The receptors CD96 and TIGIT are expressed on the surface of T and natural killer (NK) cells, and recent studies suggest both play important inhibitory roles in immune function. CD96 has been shown to modulate immune cell activity in mice, with Cd96-/- mice displaying hypersensitive NK-cell responses to immune challenge and significant tumor resistance. The counterbalance between the putative inhibitory CD96 and TIGIT receptors and the activating receptor, CD226, offers unique strategies for immuno-oncology drug development.
Product Category	Recombinant Protein / Antibody discovery / Immune checkpoint proteins

Protein	CD96/TACTILE
Synonyms	CD96 molecule; CD96; DKFZp667E2122; TACTILE
Accession	P40200-2
Species	Human
Biotinylated	no
Amino Acid Range	Val22-Met503
Molecular Weight	The protein has a predicted MW of 54.7 kDa. Due to glycosylation, the protein migrates to 115-130 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Anti-CD96 Antibody, hFc Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Human CD96, His Tag with the EC50 of 28.8ng/ml determined by ELISA (QC Test). The affinity constant of 0.958 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag	C-His
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Human CD155, hFc Tag captured on CM5 Chip via Protein A can bind Human CD96, His Tag with an affinity constant of 0.958 uM as determined in SPR assay (Biacore T200).
	Immobilized Anti-CD96 Antibody, hFc Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Human CD96, His Tag with the EC50 of 28.8ng/ml determined by ELISA (QC Test).
	Human CD96 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.