Human CDH17/Cadherin 17 Domain 1-6 Protein (CDH-HM1D1)

  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Tris-Bis PAGE
  • Activity: Immobilized Human CDH17 Domain 1-6, His Tag at 1ug/ml (100ul/Well) on the plate. Dose response curve for Anti-CDH17 Anitibody, hFc Tag with the EC50 of 3.7ng/ml determined by ELISA. See testing image for detail.
  • Exact Sequence: Gln23-Leu667

Catalog: CDH-HM1D1

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Product Description Recombinant Human CDH17/Cadherin 17 Domain 1-6 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gln23-Leu667.

Product Background

 Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.

Product Category

 Recombinant Protein

Target

 CDH17/Cadherin 17 Domain 1-6

Gene/Protein ID

 Q12864

Species

 Human

Exact Sequence

 Gln23-Leu667
Molecular Weight The protein has a predicted MW of 72.90 kDa. Due to glycosylation, the protein migrates to 90-110 kDa based on Tris-Bis PAGE result.

Activity

 Immobilized Human CDH17 Domain 1-6, His Tag at 1ug/ml (100ul/Well) on the plate. Dose response curve for Anti-CDH17 Anitibody, hFc Tag with the EC50 of 3.7ng/ml determined by ELISA. See testing image for detail.

Product Tag

 C-His

Express System

 HEK293
Purity > 95% as determined by Tris-Bis PAGE
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22 um filtered solution in 20mM Tris, 150mM NaCl (pH 8.0).. Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Immobilized Human CDH17 Domain 1-6, His Tag at 1ug/ml (100ul/Well) on the plate. Dose response curve for Anti-CDH17 Anitibody, hFc Tag with the EC50 of 3.7ng/ml determined by ELISA.
Human CDH17 Domain 1-6 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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