- Express System: HEK293
- Product Tag: C-mFc
- Purity: >95% as determined by Bis-Tris PAGE;>95% as determined by HPLC
- Activity: Immobilized Human CDH17 Domain 1, mFc Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-CDH17 Antibody, hFc Tag with the EC50 of 7.9ng/ml determined by ELISA (QC Test). See testing image for detail.
- Amino Acid Range: Gln23-Gln128
Product Description |
Recombinant Human CDH17/Cadherin 17 Domain 1 Protein is expressed from HEK293 with mFc (IgG2a) tag at the C-terminus.It contains Gln23-Gln128. |
Product Background |
Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach. |
Product Category |
Recombinant Protein |
Target |
CDH17/Cadherin 17 Domain 1 |
Synonyms |
Cadherin-17; BILL-cadherin; LI-cadherin; P130; Cdh17; CDH16; HPT-1; |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Gln23-Gln128 |
Molecular Weight |
The protein has a predicted MW of 38.29 kDa. Due to glycosylation, the protein migrates to 43-53 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Human CDH17 Domain 1, mFc Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-CDH17 Antibody, hFc Tag with the EC50 of 7.9ng/ml determined by ELISA (QC Test). See testing image for detail. |
Product Tag |
C-mFc |
Express System |
HEK293 |
Purity |
>95% as determined by Bis-Tris PAGE;>95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22 um filtered solution in PBS (pH 7.4). |
Stability And Storage |
Valid for 12 months from date of receipt when stored at -80°C.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
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