Human CDH17/Cadherin 17 Domain 1 Protein (CDH-HM31D)
Human CDH17/Cadherin 17 Domain 1 Protein (CDH-HM31D)
  • Express System: HEK293
  • Product Tag: C-mFc
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Activity: Immobilized Human CDH17 Domain 1, mFc Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-CDH17 Antibody, hFc Tag with the EC50 of 11.8ng/ml determined by ELISA. See testing image for detail.
  • Amino Acid Range: Gln23-Gln128
Catalog #CDH-HM31D
Regular price $429.00
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Human CDH17/Cadherin 17 Domain 1 Protein (CDH-HM31D) Summary

Product Description

Recombinant Human CDH17/Cadherin 17 Domain 1 Protein is expressed from HEK293 with mFc (IgG2a) tag at the C-terminus.It contains Gln23-Gln128.

Product Background

Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.

Product Category

Recombinant Protein / Antibody discovery / Antibody discovery | Others

Human CDH17/Cadherin 17 Domain 1 Protein (CDH-HM31D) Specifications/Details

Protein
CDH17/Cadherin 17
Synonyms
Cadherin-17; BILL-cadherin; LI-cadherin; P130; Cdh17; CDH16; HPT-1;
Accession
Species
Human
Biotinylated
no
Amino Acid Range
Gln23-Gln128
Molecular Weight
The protein has a predicted MW of 38.29 kDa. Due to glycosylation, the protein migrates to 43-53 kDa based on Bis-Tris PAGE result.
Activity
Immobilized Human CDH17 Domain 1, mFc Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-CDH17 Antibody, hFc Tag with the EC50 of 11.8ng/ml determined by ELISA. See testing image for detail.

Product Tag

C-mFc
Expression System
HEK293
Purity
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin
Less than 1 EU per ug by the LAL method.
Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage
-20 to -80°C for 12 months as supplied from date of receipt.; -80°C for 3 months after reconstitution.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Immobilized Human CDH17 Domain 1, mFc Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-CDH17 Antibody, hFc Tag with the EC50 of 11.8ng/ml determined by ELISA. Immobilized Human CDH17 Domain 1, mFc Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-CDH17 Antibody, hFc Tag with the EC50 of 11.8ng/ml determined by ELISA.
Human CDH17 Domain 1 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. Human CDH17 Domain 1 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
Loaded Human CDH17 Domain 1, mFc Tag on Anti-Mouse IgG Fc-Biosensor can bind Anti-CDH17 Antibody, hFc-Avi Tag with an affinity constant of 9.88 pM as determined in BLI assay (Gator® Prime). Loaded Human CDH17 Domain 1, mFc Tag on Anti-Mouse IgG Fc-Biosensor can bind Anti-CDH17 Antibody, hFc-Avi Tag with an affinity constant of 9.88 pM as determined in BLI assay (Gator® Prime).
The purity of Human CDH17 Domain 1 is greater than 95% as determined by SEC-HPLC. The purity of Human CDH17 Domain 1 is greater than 95% as determined by SEC-HPLC.
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