Human CDH17/Cadherin 17 Domain 1 Protein (CDH-HM31D)
  • Express System: HEK293
  • Product Tag: C-mFc
  • Purity: >95% as determined by Bis-Tris PAGE;>95% as determined by HPLC
  • Activity: Immobilized Human CDH17 Domain 1, mFc Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-CDH17 Antibody, hFc Tag with the EC50 of 7.9ng/ml determined by ELISA (QC Test). See testing image for detail.
  • Amino Acid Range: Gln23-Gln128
Catalog #CDH-HM31D
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Product Description
 Recombinant Human CDH17/Cadherin 17 Domain 1 Protein is expressed from HEK293 with mFc (IgG2a) tag at the C-terminus.It contains Gln23-Gln128.
Product Background
 Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.
Product Category
 Recombinant Protein
Target
 CDH17/Cadherin 17 Domain 1
Synonyms
 Cadherin-17; BILL-cadherin; LI-cadherin; P130; Cdh17; CDH16; HPT-1;
Accession
Species
 Human
Biotinylated
 no
Amino Acid Range
 Gln23-Gln128
Molecular Weight
 The protein has a predicted MW of 38.29 kDa. Due to glycosylation, the protein migrates to 43-53 kDa based on Bis-Tris PAGE result.
Activity
 Immobilized Human CDH17 Domain 1, mFc Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-CDH17 Antibody, hFc Tag with the EC50 of 7.9ng/ml determined by ELISA (QC Test). See testing image for detail.
Product Tag
 C-mFc
Express System
 HEK293
Purity
 >95% as determined by Bis-Tris PAGE;>95% as determined by HPLC
Endotoxin
 Less than 1EU per ug by the LAL method.
Form
 Liquid
Shipping
 Shipped with dry ice.
Formulation
 Supplied as 0.22 um filtered solution in PBS (pH 7.4).
Stability And Storage
 Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Immobilized Human CDH17 Domain 1, mFc Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-CDH17 Antibody, hFc Tag with the EC50 of 7.9ng/ml determined by ELISA (QC Test).
Human CDH17 Domain 1 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human CDH17 Domain 1 is greater than 95% as determined by SEC-HPLC.

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