Name: Human CDH17/Cadherin 17 Domain 3&4 Protein (CDH-HM3D3)
Brand: KactusBio
SKU: CDH-HM3D3-100UG
Price: 429.0 USD
Availability: InStock

Human CDH17/Cadherin 17 Domain 3&4 Protein (CDH-HM3D3)

Immobilized Human CDH17 Domain 3&4, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-CDH17 Domain 3 Antibody, hFc-Avi Tag with the EC50 of 22.3ng/ml determined by ELISA.

Human CDH17 Domain 3&4 on Bis-Tris PAGE under reduced condition. The purity is greater than 90%.

The purity of Human CDH17 Domain 3&4 is greater than 90% as determined by SEC-HPLC.

Express System: HEK293
Product Tag: C-mFc
Purity: > 90% as determined by Bis-Tris PAGE;> 90% as determined by HPLC
Activity: Immobilized Human CDH17 Domain 3&4, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-CDH17 Domain 3 Antibody, hFc-Avi Tag with the EC50 of 22.3ng/ml determined by ELISA.
Amino Acid Range: Val245-Phe449

Catalog #CDH-HM3D3

Size

100UG

500UG

Order by 4pm ET for delivery on:

[{"id":44198474776798,"title":"100UG","option1":"100UG","option2":null,"option3":null,"sku":"CDH-HM3D3-100UG","requires_shipping":true,"taxable":true,"featured_image":null,"available":true,"name":"Human CDH17\/Cadherin 17 Domain 3\u00264 Protein (CDH-HM3D3) - 100UG","public_title":"100UG","options":["100UG"],"price":42900,"weight":5,"compare_at_price":null,"inventory_management":"shopify","barcode":null,"requires_selling_plan":false,"selling_plan_allocations":[],"quantity_rule":{"min":1,"max":null,"increment":1}},{"id":44198573899998,"title":"500UG","option1":"500UG","option2":null,"option3":null,"sku":"CDH-HM3D3-500UG","requires_shipping":true,"taxable":true,"featured_image":null,"available":true,"name":"Human CDH17\/Cadherin 17 Domain 3\u00264 Protein (CDH-HM3D3) - 500UG","public_title":"500UG","options":["500UG"],"price":143000,"weight":5,"compare_at_price":null,"inventory_management":"shopify","barcode":null,"requires_selling_plan":false,"selling_plan_allocations":[],"quantity_rule":{"min":1,"max":null,"increment":1}}]

Human CDH17/Cadherin 17 Domain 3&4 Protein (CDH-HM3D3) Summary

Product Description	Recombinant Human CDH17/Cadherin 17 Domain 3&4 Protein is expressed from HEK293 with mFc (IgG1) tag at the C-Terminus.It contains Val245-Phe449.
Product Background	Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.
Product Category	Recombinant Protein / Antibody discovery / ADC targets

Human CDH17/Cadherin 17 Domain 3&4 Protein (CDH-HM3D3) Specifications/Details

Protein	CDH17/Cadherin 17
Synonyms	Cadherin-17; BILL-cadherin; LI-cadherin; P130; Cdh17; CDH16; HPT-1; cadherin-16;
Accession	Q12864
Species	Human
Biotinylated	no
Amino Acid Range	Val245-Phe449
Molecular Weight	The protein has a predicted MW of 49.16 kDa. Due to glycosylation, the protein migrates to 55-70 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Human CDH17 Domain 3&4, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-CDH17 Domain 3 Antibody, hFc-Avi Tag with the EC50 of 22.3ng/ml determined by ELISA.
Product Tag	C-mFc
Expression System	HEK293
Purity	> 90% as determined by Bis-Tris PAGE;> 90% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Please refer to the Certificate of Analysis for detailed instructions.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

	Immobilized Human CDH17 Domain 3&4, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-CDH17 Domain 3 Antibody, hFc-Avi Tag with the EC50 of 22.3ng/ml determined by ELISA.
	Human CDH17 Domain 3&4 on Bis-Tris PAGE under reduced condition. The purity is greater than 90%.
	The purity of Human CDH17 Domain 3&4 is greater than 90% as determined by SEC-HPLC.