Human CDH17/Cadherin 17 Domain 3&4 Protein (CDH-HM3D3)
Catalog: CDH-HM3D3
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| Product Description | Recombinant Human CDH17/Cadherin 17 Domain 3&4 Protein is expressed from HEK293 with mFc (IgG1) tag at the C-Terminus.It contains Val245-Phe449. |
Product Background |
Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach. |
Product Category |
Recombinant Protein |
Target |
CDH17/Cadherin 17 Domain 3&4 |
Gene/Protein ID |
Q12864 |
Species |
Human |
Exact Sequence |
Val245-Phe449 |
| Molecular Weight | The protein has a predicted MW of 49.16 kDa. Due to glycosylation, the protein migrates to 55-70 kDa based on Tris-Bis PAGE result. |
Product Tag |
C-mFc |
Express System |
HEK293 |
| Purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
| Endotoxin | Less than 1EU per ug by the LAL method. |
| Form | Lyophilized |
| Shipping | Shipped at ambient temperature. |
| Formulation | Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| Stability And Storage | Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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The purity of Human CDH17 Domain 3&4 is greater than 95% as determined by SEC-HPLC. |
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Human CDH17 Domain 3&4 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
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