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Human CDH17/Cadherin 17 Domain 3 Protein, Ultra Low Endotoxin (CDH-HM33D-UL) Summary
Product Description |
Recombinant Human CDH17/Cadherin 17 Domain 3 Protein is expressed from HEK293 with mFc (IgG2a) tag at the C-terminus.It contains Val245-Cys340. |
Product Background |
Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach. |
Product Category |
Recombinant Protein / Antibody discovery / ADC targets |
Human CDH17/Cadherin 17 Domain 3 Protein, Ultra Low Endotoxin (CDH-HM33D-UL) Specifications/Details
Protein |
CDH17/Cadherin 17 |
Synonyms |
Cadherin-17; BILL-cadherin; LI-cadherin; P130; Cdh17; CDH16; HPT-1; |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Val245-Cys340 |
Molecular Weight |
The protein has a predicted MW of 37.46 kDa. Due to glycosylation, the protein migrates to 50-65 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Human CDH17 Domain 3, mFc Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-CDH17 Domain 3 Antibody, hFc Avi Tag with the EC50 of 25.9ng/ml determined by ELISA. |
Product Tag |
C-mFc |
Fluorophore |
Unconjugated |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE |
Endotoxin |
Less than 0.01 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.； -80°C for 3 months after reconstitution.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
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Immobilized Human CDH17 Domain 3, mFc Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-CDH17 Domain 3 Antibody, hFc Avi Tag with the EC50 of 25.9ng/ml determined by ELISA. |
|
|
Human CDH17 Domain 3 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
Other Available Proteins:
Finding available proteins...
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