Human CDH17/Cadherin 17 Domain 4 Protein, Ultra Low Endotoxin (CDH-HM34D-UL)

SKU: CDH-HM34D-UL-100UG

Human CDH17/Cadherin 17 Domain 4 Protein, Ultra Low Endotoxin (CDH-HM34D-UL)

SKU: CDH-HM34D-UL-100UG
Human CDH17/Cadherin 17 Domain 4 Protein, Ultra Low Endotoxin (CDH-HM34D-UL)
  • Express System: HEK293
  • Product Tag: C-mFc
  • Purity: > 95% as determined by Bis-Tris PAGE
  • Amino Acid Range: Pro341-Phe449
Catalog #CDH-HM34D-UL
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Size
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Human CDH17/Cadherin 17 Domain 4 Protein, Ultra Low Endotoxin (CDH-HM34D-UL) Summary

Product Description

 Recombinant Human CDH17/Cadherin 17 Domain 4 Protein is expressed from HEK293 with mFc (IgG2a) tag at the C-terminus.It contains Pro341-Phe449.

Product Background

 Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.

Product Category

 Recombinant Protein / Antibody discovery / ADC targets

Human CDH17/Cadherin 17 Domain 4 Protein, Ultra Low Endotoxin (CDH-HM34D-UL) Specifications/Details

Protein
 CDH17/Cadherin 17
Synonyms
 Cadherin-17; BILL-cadherin; LI-cadherin; P130; Cdh17; CDH16; HPT-1;
Accession
Species
 Human
Biotinylated
 no
Amino Acid Range
 Pro341-Phe449
Molecular Weight
 The protein has a predicted MW of 38.78 kDa. Due to glycosylation, the protein migrates to 45-60 kDa based on Bis-Tris PAGE result.
Product Tag
 C-mFc

Fluorophore

 Unconjugated
Expression System
 HEK293
Purity
 > 95% as determined by Bis-Tris PAGE
Endotoxin
 Less than 0.01 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form
 Lyophilized
Shipping
 Shipped at ambient temperature.
Formulation
 Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
 Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage
 -20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

Human CDH17 Domain 4 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. Human CDH17 Domain 4 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
Other Available Proteins:
Finding available proteins...
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