Human CDH17/Cadherin 17 Domain 6-7 Protein (CDH-HM3D2)
Human CDH17/Cadherin 17 Domain 6-7 Protein (CDH-HM3D2)
Human CDH17/Cadherin 17 Domain 6-7 Protein (CDH-HM3D2)
Human CDH17/Cadherin 17 Domain 6-7 Protein (CDH-HM3D2)
  • Express System: HEK293
  • Product Tag: C-mFc
  • Purity: >95% as determined by Bis-Tris PAGE;>90% as determined by HPLC
  • Amino Acid Range: Ser567-Gly777
Catalog #CDH-HM3D2
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Product Description
 Recombinant Human CDH17/Cadherin 17 Domain 6-7 Protein is expressed from HEK293 with mFc (IgG1) tag at the C-Terminus.It contains Ser567-Gly777.
Product Background
 Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades. In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.
Product Category
 Recombinant Protein
Target
 CDH17/Cadherin 17 Domain 6-7
Synonyms
 Cadherin-17; BILL-cadherin; LI-cadherin; P130; Cdh17; CDH16; HPT-1; cadherin-16; FLJ26931; MGC138218; MGC142024
Accession
Species
 Human
Biotinylated
 no
Amino Acid Range
 Ser567-Gly777
Molecular Weight
 The protein has a predicted MW of 50.18 kDa. Due to glycosylation, the protein migrates to 55-65 kDa based on Bis-Tris PAGE result.
Product Tag
 C-mFc
Express System
 HEK293
Purity
 >95% as determined by Bis-Tris PAGE;>90% as determined by HPLC
Endotoxin
 Less than 1 EU per ug by the LAL method.
Form
 Lyophilized
Shipping
 Shipped at ambient temperature.
Formulation
 Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
 Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
 Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Human CDH17 Domain 6-7 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human CDH17 Domain 6-7 is greater than 90% as determined by SEC-HPLC.

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