Product Description |
Recombinant Human CDH17/Cadherin 17 Domain 6 Protein is expressed from HEK293 with mFc (IgG2a) tag at the C-terminus.It contains Ser567-Leu667. |
Product Background |
Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach. |
Product Category |
Recombinant Protein |
Protein |
CDH17/Cadherin 17 Domain 6 |
Synonyms |
Cadherin-17; BILL-cadherin; LI-cadherin; P130; Cdh17; CDH16; HPT-1; |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Ser567-Leu667 |
Molecular Weight |
The protein has a predicted MW of 37.24 kDa. Due to glycosylation, the protein migrates to 45-55 kDa based on Bis-Tris PAGE result. |
Product Tag |
C-mFc |
Expression System |
HEK293 |
Purity |
>95% as determined by Bis-Tris PAGE;>95% as determined by HPLC |
Endotoxin |
Less than 0.1EU per ug by the LAL method. |
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22 um filtered solution in PBS, 200mM L-arginine (pH 7.4). |
Stability And Storage |
Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
|
|
Human CDH17 Domain 6 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
|
The purity of Human CDH17 Domain 6 is greater than 95% as determined by SEC-HPLC. |
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