Human CDH17/Cadherin 17 Domain 7 Protein (CDH-HM2D3)

  • Express System: HEK293
  • Product Tag: C-hFc
  • Purity: > 95% as determined by Tris-Bis PAGE
  • Exact Sequence: Ala668-Gly777

Catalog: CDH-HM2D3

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Product Description Recombinant Human CDH17/Cadherin 17 Domain 7 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Ala668-Gly777.

Product Background

Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.

Product Category

Recombinant Protein

Target

CDH17/Cadherin 17 Domain 7
Accession

Species

Human

Exact Sequence

Ala668-Gly777
Molecular Weight The protein has a predicted MW of 38.42 kDa. Due to glycosylation, the protein migrates to 48-52 kDa based on Tris-Bis PAGE result.

Product Tag

C-hFc

Express System

HEK293
Purity > 95% as determined by Tris-Bis PAGE
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22 um filtered solution in 20mM Tris, 150mM NaCl (pH 8.0). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Human CDH17 Domain 7 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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