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Human CDH17/Cadherin 17 Protein, Ultra Low Endotoxin (CDH-HM217-UL) Summary
Product Description |
Recombinant Human CDH17/Cadherin 17 Protein is expressed from HEK293 with hFc (IgG1) tag at the C-Terminus.It contains Gln23-Met787. |
Product Background |
Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach. |
Product Category |
Recombinant Protein / Antibody discovery / ADC targets |
Human CDH17/Cadherin 17 Protein, Ultra Low Endotoxin (CDH-HM217-UL) Specifications/Details
Protein |
CDH17/Cadherin 17 |
Synonyms |
Cadherin-17; BILL-cadherin; LI-cadherin; P130; Cdh17; CDH16; HPT-1; cadherin-16; FLJ26931; MGC138218; MGC142024 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Gln23-Met787 |
Molecular Weight |
The protein has a predicted MW of 111.73 kDa. Due to glycosylation, the protein migrates to 113-135 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Human CDH17, hFc Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-CDH17 Antibody, hFc Tag with the EC50 of 15.1ng/ml determined by ELISA. |
Product Tag |
C-hFc (IgG1) |
Fluorophore |
Unconjugated |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 0.01 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
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Immobilized Human CDH17, hFc Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-CDH17 Antibody, hFc Tag with the EC50 of 15.1ng/ml determined by ELISA. |
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Human CDH17 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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Loaded Biotinylated Anti-CDH17 Antibody, hFc-Avi Tag on Streptavidin-Biosensor can bind Human CDH17, hFc Tag with an affinity constant of 0.14 nM as determined in BLI assay . |
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The purity of Human CDH17 is greater than 95% as determined by SEC-HPLC. |
Other Available Proteins:
Finding available proteins...
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