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Human CDH3/Cadherin 3 Protein, Ultra Low Endotoxin (CDH-HM103-UL) Summary
Product Description |
Recombinant Human CDH3/Cadherin 3 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Asp108-Gly654. |
Product Background |
Placental-Cadherin (CDH3), a cell adhesion molecule, is associated with the function of cells to bind with other cells and the extracellular matrix (ECM). CDH3 is highly expressed in many malignancies, and has been proved it could be a serum marker to monitor colorectal cancer. Inhibited CDH3 expression could upregulate E-cadherin, downregulated N-cadherin, which may control invasion and migration. |
Product Category |
Recombinant Protein / Antibody discovery / ADC targets |
Human CDH3/Cadherin 3 Protein, Ultra Low Endotoxin (CDH-HM103-UL) Specifications/Details
Protein |
CDH3/Cadherin 3 |
Synonyms |
Cadherin-3;Placental cadherin;P-cadherin;CDH3;CDHP;HJMD;PCAD;PCADP-cadherin;CAD3 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Asp108-Gly654 |
Molecular Weight |
The protein has a predicted MW of 61.11 kDa. Due to glycosylation, the protein migrates to 70-80 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Anti-CDH3 Antibody, hFc Tag at 2ug/ml (100ul/Well) on the plate. Dose response curve for Human CDH3, His Tag with the EC50 of 1.12ug/ml determined by ELISA (QC Test). |
Product Tag |
C-His |
Fluorophore |
Unconjugated |
Expression System |
HEK293 |
Purity |
> 90% as determined by Bis-Tris PAGE |
Endotoxin |
Less than 0.01 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 24 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
|
|
Immobilized Anti-CDH3 Antibody, hFc Tag at 2ug/ml (100ul/Well) on the plate. Dose response curve for Human CDH3, His Tag with the EC50 of 1.12ug/ml determined by ELISA (QC Test). |
|
|
Human CDH3 on Bis-Tris PAGE under reduced condition. The purity is greater than 90%. |
Other Available Proteins:
Finding available proteins...
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