Human CEACAM-7 Protein (CEA-HM107)
Human CEACAM-7 Protein (CEA-HM107)
Human CEACAM-7 Protein (CEA-HM107)
Human CEACAM-7 Protein (CEA-HM107)
  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Activity: Immobilized Human CEACAM-7, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Human CEACAM-3, hFc Tag with the EC50 of 31.1ng/ml determined by ELISA (QC Test). The affinity constant of 0.37 uM as determined in SPR assay (Biacore T200). See testing image for detail.
  • Amino Acid Range: Thr36-Ser242
Catalog #CEA-HM107
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Product Description
 Recombinant Human CEACAM-7 Protein is expressed from HEK293 with His tag at the C-terminus.It contains Thr36-Ser242.
Product Background
 Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) belong to a group of mammalian immunoglobulin-related glycoproteins. They are involved in cell–cell recognition and modulate cellular processes that range from the shaping of tissue architecture and neovascularization to the regulation of insulin homeostasis and T-cell proliferation. CEACAM7 (CGM2), a member of the CEA family of proteins with expression restricted to the colon and pancreas, as a potential CAR T-cell target for PDAC.
Product Category
 Recombinant Protein
Target
 CEACAM-7
Accession
Species
 Human
Biotinylated
 no
Amino Acid Range
 Thr36-Ser242
Molecular Weight
 The protein has a predicted MW of 24.45 kDa. Due to glycosylation, the protein migrates to 45-65 kDa based on Bis-Tris PAGE result.
Activity
 Immobilized Human CEACAM-7, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Human CEACAM-3, hFc Tag with the EC50 of 31.1ng/ml determined by ELISA (QC Test). The affinity constant of 0.37 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag
 C-His
Express System
 HEK293
Purity
 > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin
 Less than 1EU per ug by the LAL method.
Form
 Lyophilized
Shipping
 Shipped at ambient temperature.
Formulation
 Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
 Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
 Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Human CEACAM-1, His Tag immobilized on CM5 Chip can bind Human CEACAM-7, His Tag- with an affinity constant of 0.37 uM as determined in SPR assay (Biacore T200).
Immobilized Human CEACAM-7, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Human CEACAM-3, hFc Tag with the EC50 of 31.1ng/ml determined by ELISA (QC Test).
Human CEACAM-7 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human CEACAM-7 is greater than 95% as determined by SEC-HPLC.
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