ELISA binding curve showing human CEACAM-7 interaction with CEACAM-3 using hFc-tagged proteins, measured by OD450.
  • Express System: HEK293
  • Product Tag: C-hFc
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Activity: Immobilized Human CEACAM-3, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Human CEACAM-7, hFc Tag with the EC50 of 26.5ng/ml determined by ELISA. See testing image for detail.
  • Amino Acid Range: Thr36-Ser242
Catalog #CEA-HM207
Regular price $297.00
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Human CEACAM-7 Protein (CEA-HM207) Summary

Product Description

Recombinant Human CEACAM-7 Protein is expressed from HEK293 with hFc tag at the C-terminus.It contains Thr36-Ser242.

Product Background

Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) belong to a group of mammalian immunoglobulin-related glycoproteins. They are involved in cell–cell recognition and modulate cellular processes that range from the shaping of tissue architecture and neovascularization to the regulation of insulin homeostasis and T-cell proliferation. CEACAM7 (CGM2), a member of the CEA family of proteins with expression restricted to the colon and pancreas, as a potential CAR T-cell target for PDAC.

Product Category

Recombinant Protein / Antibody discovery / CAR-T targets

Human CEACAM-7 Protein (CEA-HM207) Specifications/Details

Protein
CEACAM-7
Synonyms
CGM2; CEACAM7; CEA
Accession
Species
Human
Biotinylated
no
Amino Acid Range
Thr36-Ser242
Molecular Weight
The protein has a predicted MW of 50.11 kDa. Due to glycosylation, the protein migrates to 68-78 kDa based on Bis-Tris PAGE result.
Activity
Immobilized Human CEACAM-3, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Human CEACAM-7, hFc Tag with the EC50 of 26.5ng/ml determined by ELISA. See testing image for detail.

Product Tag

C-hFc
Expression System
HEK293
Purity
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin
Less than 1 EU per ug by the LAL method.
Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage
-20 to -80°C for 12 months as supplied from date of receipt.;-80°C for 3 months after reconstitution.;Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Immobilized Human CEACAM-3, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Human CEACAM-7, hFc Tag with the EC50 of 26.5ng/ml determined by ELISA. Immobilized Human CEACAM-3, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Human CEACAM-7, hFc Tag with the EC50 of 26.5ng/ml determined by ELISA.
Human CEACAM-7 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. Human CEACAM-7 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human CEACAM-7 is greater than 95% as determined by SEC-HPLC. The purity of Human CEACAM-7 is greater than 95% as determined by SEC-HPLC.
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