Product Description |
Recombinant Human CEACAM-8/CD66b Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gln35-Ser319. |
Product Background |
Eosinophils and their products are likely important in the pathophysiology of allergic diseases, such as bronchial asthma, and in host immunity to parasitic organisms. CD66b (CEACAM8, CGM6, NCA-95) is a single chain, GPI-anchored, highly glycosylated protein belonging to the carcinoembryonic Ag supergene family. CD66b is an activation marker for human granulocytes. |
Product Category |
Recombinant Protein |
Target |
CEACAM-8/CD66b |
Synonyms |
CD66b; CEACAM8; CGM6; CD67; NCA-95 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Gln35-Ser319 |
Molecular Weight |
The protein has a predicted MW of 32.5 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result. |
Activity |
The affinity constant of 4.59 uM as determined in SPR assay (Biacore T200). See testing image for detail. |
Product Tag |
C-His |
Express System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
|
|
Human CEACAM-8, His Tag immobilized on CM5 Chip can bind Human CEACAM-6, His Tag with an affinity constant of 4.59 uM as determined in SPR assay (Biacore T200). |
|
|
Human CEACAM-8 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
|
The purity of Human CEACAM-8 is greater than 95% as determined by SEC-HPLC. |
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