Product Description |
Recombinant Human CHRDL1 Protein is expressed from E.coli with His tag at the N-Terminus.It contains Glu28-Cys456. |
Product Background |
CHRDL1 (Chordin-like 1) is a secreted protein that acts as an antagonist of bone morphogenetic protein (BMP). BMP plays a role as an activator of BMP receptor II (BMPR II), which mediates extracellular to intracellular signal transmission and is involved in carcinogenesis and metastasis.The hypermethylation of the CHRDL1 promoter in gastric cancer, which induced low expression of CHRDL1 and decreased its secretion to the supernatant. |
Product Category |
Recombinant Protein |
Target |
CHRDL1 |
Synonyms |
Neuralin-1; Neurogenesin-1; Ventroptin; CHRDL1; NRLN1; CHL; Chordin-like 1; CRDL1; dA141H5.1; VOPT |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Glu28-Cys456 |
Molecular Weight |
The protein has a predicted MW of 50 kDa same as Bis-Tris PAGE result. |
Activity |
Immobilized Human CHRDL1, His Tag at 1ug/ml (100ul/Well) on the plate. Dose response curve for Anti-CHRDL1 Antibody, hFc Tag with the EC50 of 6.7ng/ml determined by ELISA (QC Test). See testing image for detail. |
Product Tag |
N-His |
Express System |
E.coli |
Purity |
> 90% as determined by Bis-Tris PAGE |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in 4mM HCl. Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in 4mM HCl. |
Stability And Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
|
|
Immobilized Human CHRDL1, His Tag at 1ug/ml (100ul/Well) on the plate. Dose response curve for Anti-CHRDL1 Antibody, hFc Tag with the EC50 of 6.7ng/ml determined by ELISA (QC Test). |
|
|
Human CHRDL1 on Bis-Tris PAGE under reduced condition. The purity is greater than 90%. |
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