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Human CLEC12A/MICL/CLL-1 Protein, Ultra Low Endotoxin (CLE-HM22A-UL) Summary
Product Description |
Recombinant Human CLEC12A/MICL/CLL-1 Protein is expressed from HEK293 with hFc (IgG1) tag at the N-Terminus.It contains His65-Ala265. |
Product Background |
CLEC12A has recently been identified as an antigen, expressed on leukemic stem cells and leukemic blasts. Given the fact that this expression profile seems stable throughout diagnosis, treatment and relapse on leukemic blasts and leukemic stem cells, CLEC12A can be considered a highly potent and reliable marker for the detection of measurable residual disease and therefore applicable for risk stratification and prognostication in AML. |
Product Category |
Recombinant Protein / Antibody discovery / CAR-T targets, ADC targets |
Human CLEC12A/MICL/CLL-1 Protein, Ultra Low Endotoxin (CLE-HM22A-UL) Specifications/Details
Protein |
CLEC12A/MICL/CLL-1 |
Synonyms |
MICL; CLL-1; CLEC12A; CLL1; DCAL2; DCAL-2; CD371; CD303; CLECSF11; CLECSF7; DLEC; HECL; PRO34150; DCAL-2 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
His65-Ala265 |
Molecular Weight |
The protein has a predicted MW of 50.9 kDa. Due to glycosylation, the protein migrates to 68-73 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Human CLEC12A, hFc Tag at 0.5ug/ml (100ul/Well) on the plate. Dose response curve for Biotinylated Anti-CLEC12A Antibody, hFc Tag with the EC50 of 31.2ng/ml determined by ELISA. |
Product Tag |
N-hFc (IgG1) |
Fluorophore |
Unconjugated |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 0.01 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
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Immobilized Human CLEC12A, hFc Tag at 0.5ug/ml (100ul/Well) on the plate. Dose response curve for Biotinylated Anti-CLEC12A Antibody, hFc Tag with the EC50 of 31.2ng/ml determined by ELISA. |
|
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Human CLEC12A on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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The purity of Human CLEC12A is greater than 95% as determined by SEC-HPLC. |
Other Available Proteins:
Finding available proteins...
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