Human Clusterin Protein (CLN-HM101)

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Tris-Bis PAGE
Activity: Immobilized Human Clusterin, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-Clusterin Antibody, hFc Tag with the EC50 of 49.2ng/ml determined by ELISA. See testing image for detail.
Exact Sequence: Asp23-Glu449

Catalog: CLN-HM101

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Product Description	Recombinant Human Clusterin Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Asp23-Glu449.
Product Background	Clusterin (CLU) is a stress-activated, ATP-independent molecular chaperone, normally secreted from cells, that is up-regulated in Alzheimer disease and in many cancers. It plays important roles in protein homeostasis/proteostasis, inhibition of cell death pathways, and modulation of pro-survival signalling and transcriptional networks. Changes in the CLU gene locus are highly associated with Alzheimer disease, and many therapy-resistant cancers over-express CLU.
Product Category	Recombinant Protein

Target	Clusterin
Synonyms	Clusterin; Apolipoprotein J; Apo-J; Clustrin; SGP-2; Msgp-2; CLU; AAG4; APOJ; CLI; KUB1; SP-40; TRPM2; CLI; CLU1; CLU2; KUB1; NA1/NA2; KUB1SGP2; MGC24903
Gene/Protein ID	P10909-1
Species	Human
Exact Sequence	Asp23-Glu449
Molecular Weight	The protein has a predicted MW of 51.2 kDa. The protein migrates to 38-41 kDa based on Tris-Bis PAGE result.
Activity	Immobilized Human Clusterin, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-Clusterin Antibody, hFc Tag with the EC50 of 49.2ng/ml determined by ELISA. See testing image for detail.
Product Tag	C-His
Express System	HEK293
Purity	> 95% as determined by Tris-Bis PAGE
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

	Immobilized Human Clusterin, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-Clusterin Antibody, hFc Tag with the EC50 of 49.2ng/ml determined by ELISA.
	Human Clusterin on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.