Human Clusterin Protein (CLN-HM101)
Human Clusterin Protein (CLN-HM101)
Human Clusterin Protein (CLN-HM101)
  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Bis-Tris PAGE
  • Activity: Immobilized Human Clusterin, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-Clusterin Antibody, hFc Tag with the EC50 of 9.0ng/ml determined by ELISA. See testing image for detail.
  • Amino Acid Range: Asp23-Glu449
Catalog #CLN-HM101
Regular price $270.00
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Product Description
Recombinant Human Clusterin Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Asp23-Glu449.
Product Background
Clusterin (CLU) is a stress-activated, ATP-independent molecular chaperone, normally secreted from cells, that is up-regulated in Alzheimer disease and in many cancers. It plays important roles in protein homeostasis/proteostasis, inhibition of cell death pathways, and modulation of pro-survival signalling and transcriptional networks. Changes in the CLU gene locus are highly associated with Alzheimer disease, and many therapy-resistant cancers over-express CLU.
Product Category
Recombinant Protein
Target
Clusterin
Synonyms
Clusterin; Apolipoprotein J; Apo-J; Clustrin; SGP-2; Msgp-2; CLU; AAG4; APOJ; CLI; KUB1; SP-40; TRPM2; CLI; CLU1; CLU2; KUB1; NA1/NA2; KUB1SGP2; MGC24903
Accession
Species
Human
Biotinylated
no
Amino Acid Range
Asp23-Glu449
Molecular Weight
The protein has a predicted MW of 51.2 kDa. The protein migrates to 38-41 kDa based on Bis-Tris PAGE result.
Activity
Immobilized Human Clusterin, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-Clusterin Antibody, hFc Tag with the EC50 of 9.0ng/ml determined by ELISA. See testing image for detail.
Product Tag
C-His
Express System
HEK293
Purity
> 95% as determined by Bis-Tris PAGE
Endotoxin
Less than 1EU per ug by the LAL method.
Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Immobilized Human Clusterin, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-Clusterin Antibody, hFc Tag with the EC50 of 9.0ng/ml determined by ELISA.
Human Clusterin on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

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