Human DcR1/TRAILR3 Protein (TRA-HM103)
  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Activity: The affinity constant of 0.57 nM as determined in SPR assay (Biacore T200). See testing image for detail.
  • Amino Acid Range: Tyr24-Ala236
Catalog #TRA-HM103
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Product Description
 Recombinant Human DcR1/TRAILR3 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Tyr24-Ala236.
Product Background
 The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the TNF family, which mediates apoptosis by the extrinsic pathway. Up-regulation of decoy receptors, DcR1 and DcR2, may result in diminished binding of TRAIL to their functional receptors. DcR1 expression occurs in a subset of EC and may contribute to resistance to TRAIL-induced apoptosis.
Product Category
 Recombinant Protein
Target
 DcR1/TRAILR3
Synonyms
 CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3; TRAILR3; TRID; TNFRSF10C
Accession
Species
 Human
Biotinylated
 no
Amino Acid Range
 Tyr24-Ala236
Molecular Weight
 The protein has a predicted MW of 23.5 kDa. Due to glycosylation, the protein migrates to 60-80 kDa based on Bis-Tris PAGE result.
Activity
 The affinity constant of 0.57 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag
 C-His
Express System
 HEK293
Purity
 > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin
 Less than 1EU per ug by the LAL method.
Form
 Lyophilized
Shipping
 Shipped at ambient temperature.
Formulation
 Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
 Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
 Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Human DcR1, His Tag immobilized on CM5 Chip can bind Human TRAIL, No Tag with an affinity constant of 0.57 nM as determined in SPR assay (Biacore T200).
Human DcR1/TRAILR3 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human DcR1/TRAILR3 is greater than 95% as determined by SEC-HPLC.
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