Name: Human DDR1 Protein (DDR-HM1R1)
Brand: KactusBio
SKU: DDR-HM1R1-100UG
Price: 270.0 USD
Availability: InStock

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Human DDR1, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-DDR1 Antibody, hFc Tag with the EC50 of 12.5ng/ml determined by ELISA (QC Test). The affinity constant of 0.806 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Amino Acid Range: Asp21-Ala417

Catalog #DDR-HM1R1

Size

100UG

500UG

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Product Description	Recombinant Human DDR1 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Asp21-Ala417.
Product Background	Discoidin domain receptor1 (DDR1) is a collagen activated receptor tyrosine kinase and an attractive anti-fibrotic target. Its expression is mainly limited to epithelial cells located in several organs including skin, kidney, liver and lung. DDR1's biology is elusive, with unknown downstream activation pathways; however, it may act as a mediator of the stromal-epithelial interaction, potentially controlling the activation state of the resident quiescent fibroblasts.
Product Category	Recombinant Protein / Antibody discovery

Protein	DDR1
Synonyms	HGK2; MCK-10; CAK; EDDR1; NEP; NTRK4; PTK3A; RTK6; TRKE; CD167a; EC 2.7.10.1
Accession	Q08345-1
Species	Human
Biotinylated	no
Amino Acid Range	Asp21-Ala417
Molecular Weight	The protein has a predicted MW of 45.1 kDa. Due to glycosylation, the protein migrates to 63-67 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Human DDR1, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-DDR1 Antibody, hFc Tag with the EC50 of 12.5ng/ml determined by ELISA (QC Test). The affinity constant of 0.806 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag	C-His
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Human DDR1, His Tag captured on CM5 Chip via Anti-His Antibody can bind Native Human Collagen I protein with an affinity constant of 0.806 nM as determined in SPR assay (Biacore T200).
	Immobilized Human DDR1, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-DDR1 Antibody, hFc Tag with the EC50 of 12.5ng/ml determined by ELISA (QC Test).
	Human DDR1 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Human DDR1 is greater than 95% as determined by SEC-HPLC.