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Human DDR1 Protein, Ultra Low Endotoxin (DDR-HM2R1-UL) Summary
Product Description |
Recombinant Human DDR1 Protein is expressed from HEK293 with hFc (IgG1) tag at the C-terminus.It contains Asp21-Ala417. |
Product Background |
Discoidin domain receptor1 (DDR1) is a collagen activated receptor tyrosine kinase and an attractive anti-fibrotic target. Its expression is mainly limited to epithelial cells located in several organs including skin, kidney, liver and lung. DDR1's biology is elusive, with unknown downstream activation pathways; however, it may act as a mediator of the stromal-epithelial interaction, potentially controlling the activation state of the resident quiescent fibroblasts. |
Product Category |
Recombinant Protein / Antibody discovery / ADC targets |
Human DDR1 Protein, Ultra Low Endotoxin (DDR-HM2R1-UL) Specifications/Details
Protein |
DDR1 |
Synonyms |
HGK2; MCK-10; CAK; EDDR1; NEP; NTRK4; PTK3A; RTK6; TRKE; CD167a; EC 2.7.10.1 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Asp21-Ala417 |
Molecular Weight |
The protein has a predicted MW of 69.97 kDa. Due to glycosylation, the protein migrates to 80-100 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Human DDR1, hFc Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-DDR1 Antibody, hFc Tag with the EC50 of 13.6ng/ml determined by ELISA. |
Product Tag |
C-hFc (IgG1) |
Fluorophore |
Unconjugated |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 90% as determined by HPLC |
Endotoxin |
Less than 0.01 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
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Immobilized Human DDR1, hFc Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-DDR1 Antibody, hFc Tag with the EC50 of 13.6ng/ml determined by ELISA. |
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Human DDR1 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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The purity of Human DDR1 is greater than 90% as determined by SEC-HPLC. |
Other Available Proteins:
Finding available proteins...
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