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Human HLA-A*01:01&B2M&DSG3 (YTDNWLAVY) Monomer Protein (MHC-HM428) Summary
Product Description |
Recombinant Human HLA-A*01:01&B2M&DSG3 (YTDNWLAVY) Monomer Protein is expressed from HEK293 with His tag and Avi Tag at the C-Terminus.It contains Gly25-Thr305(HLA-A*01:01), Ile21-Met119(B2M) and YTDNWLAVY peptide.. |
Product Background |
DSG3 is overexpressed in head neck cancer and is a potential molecular target for inhibition of oncogenesis. DSG3 is identified overexpressed in HNC, with the degree of overexpression associated with clinicopathologic features of the tumor. Inhibition of DSG3 significantly suppresses carcinogenic potential in cellular and in vivo animal studies. These findings suggest that DSG3 is a potential molecular target in the development of adjuvant therapy for HNC. |
Product Category |
Recombinant Protein / Antibody discovery / MHC / Peptide-MHCs |
HLA-A*01:01&B2M&DSG3 (YTDNWLAVY) Specifications
Protein |
HLA-A*01:01&B2M&DSG3 (YTDNWLAVY) |
Synonyms |
DSG3; DSG-3; Desmoglein-3; PVA; CDHF6; DG3 |
MHC Form |
Monomer |
Allele |
HLA-A*01:01 |
Accession |
Q5SUL5(HLA-A*01:01)&P61769(B2M)&YTDNWLAVY |
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Gly25-Thr305(HLA-A*01:01), Ile21-Met119(B2M)and YTDNWLAVY peptide. |
Molecular Weight |
The protein has a predicted MW of 50.50 kDa. Due to glycosylation, the protein migrates to 52-62 kDa based on Bis-Tris PAGE result. |
Product Tag |
C-His-Avi |
Fluorophore |
Unconjugated |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
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Human HLA-A*01:01&B2M&DSG3 (YTDNWLAVY) Monomer on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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The purity of Human HLA-A*01:01&B2M&DSG3 (YTDNWLAVY) Monomer is greater than 95% as determined by SEC-HPLC. |
Additional Information
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