Human DSG3 Protein (DSG-HM103)

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Activity: Immobilized Human DSG3, His Tag at 0.5ug/ml (100ul/Well) on the plate. Dose response curve for Anti-DSG3 Antibody, hFc Tag with the EC50 2.1ng/ml determined by ELISA. See testing image for detail.
Exact Sequence: Glu50-Arg615

Catalog: DSG-HM103

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Product Description	Recombinant Human DSG3 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Glu50-Arg615.
Product Background	To identify genes that could potentially serve as molecular therapeutic markers for human head and neck cancer (HNC),DSG3 is identified overexpressed in HNC, with the degree of overexpression associated with clinicopathologic features of the tumor. Inhibition of DSG3 significantly suppresses carcinogenic potential in cellular and in vivo animal studies. DSG3 is a potential molecular target in the development of adjuvant therapy for HNC.
Product Category	Recombinant Protein

Target	DSG3
Synonyms	Desmoglein-3; PVA; CDHF6; SG3; DSG3
Gene/Protein ID	P32926
Species	Human
Exact Sequence	Glu50-Arg615
Molecular Weight	The protein has a predicted MW of 64 kDa. Due to glycosylation, the protein migrates to 70-75 kDa based on Tris-Bis PAGE result.
Activity	Immobilized Human DSG3, His Tag at 0.5ug/ml (100ul/Well) on the plate. Dose response curve for Anti-DSG3 Antibody, hFc Tag with the EC50 2.1ng/ml determined by ELISA. See testing image for detail.
Product Tag	C-His
Express System	HEK293
Purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

	Immobilized Human DSG3, His Tag at 0.5ug/ml (100ul/Well) on the plate. Dose response curve for Anti-DSG3 Antibody, hFc Tag with the EC50 2.1ng/ml determined by ELISA.
	The purity of Human DSG3 is greater than 95% as determined by SEC-HPLC.
	Human DSG3 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.