Product Description |
Recombinant Human EPHA3 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Glu21-Gln541. |
Product Background |
Erythropoietin‑producing hepatocellular carcinoma cell surface type‑A receptor 3 (EPHA3) has been found to promote the proliferation and survival of prostate cancer (PCa) cell lines and prostate tumor development in nude mice. The interaction of AR and SP1 contributes to regulate EPHA3 expression, and the SP1 binding sites (‑295~‑261) in the EPHA3 core promoter region is crucial to the regulation of EPHA3 expression in response to androgen hormone stimuli. |
Product Category |
Recombinant Protein |
Target |
EPHA3 |
Synonyms |
EK4; HEK; ETK; ETK1; EPHA3; TYRO4; HEK4 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Glu21-Gln541 |
Molecular Weight |
The protein has a predicted MW of 59.9 kDa. Due to glycosylation, the protein migrates to 70-75 kDa based on Bis-Tris PAGE result. |
Product Tag |
C-His |
Express System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
|
|
Human EPHA3 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
|
The purity of Human EPHA3 is greater than 95% as determined by SEC-HPLC. |
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