Name: Human EPHA4 Protein (EPH-HM104)
Brand: KactusBio
SKU: EPH-HM104-100UG
Price: 297.0 USD
Availability: InStock

Catalog #EPH-HM104

Size

100UG

500UG

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Product Description	Recombinant Human EPHA4 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Val20-Thr547.
Product Background	The expression and activation of EphA4 in the various cell types in a knee joint was upregulated upon an intraarticular injury. To determine if EphA4 signaling plays a role in osteoarthritis, we determined whether deficient EphA4 expression (in EphA4 knockout mice) or upregulation of the EphA4 signaling (with the EfnA4-fc treatment) would alter cellular functions of synoviocytes and articular chondrocytes. In synoviocytes, deficient EphA4 expression enhanced, whereas activation of the EphA4 signaling reduced, expression and secretion of key inflammatory cytokines and matrix metalloproteases.
Product Category	Recombinant Protein / Antibody discovery

Protein	EPHA4
Synonyms	Sek; Sek1; EphA4; HEK8; SEK; TYRO1; EK8
Accession	P54764-1
Species	Human
Biotinylated	no
Amino Acid Range	Val20-Thr547
Molecular Weight	The protein has a predicted MW of 59.5 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result.
Product Tag	C-His
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 0.1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Human EPHA4 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Human EPHA4 is greater than 95% as determined by SEC-HPLC.