Product Description |
Recombinant Human EREG Protein is expressed from HEK293 with hFc tag at the N-Terminus.It contains Val63-Leu108. |
Product Background |
Epidermal growth factor receptor (EGFR) regulates many crucial cellular programs, with seven different activating ligands shaping cell signaling in distinct ways.EGFR ligands epiregulin (EREG) and epigen (EPGN) stabilize different dimeric conformations of the EGFR extracellular region. As a consequence, EREG or EPGN induce less stable EGFR dimers than EGF-making them partial agonists of EGFR dimerization. Unexpectedly, this weakened dimerization elicits more sustained EGFR signaling than seen with EGF, provoking responses in breast cancer cells associated with differentiation rather than proliferation. |
Product Category |
Recombinant Protein |
Protein |
EREG |
Synonyms |
Proepiregulin; EPR; Epiregulin; EREG; ER |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Val63-Leu108 |
Molecular Weight |
The protein has a predicted MW of 32.6 kDa. Due to glycosylation, the protein migrates to 37-42 kDa based on Bis-Tris PAGE result. |
Product Tag |
N-hFc |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
|
|
Human EREG on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
|
The purity of Human EREG is greater than 95% as determined by SEC-HPLC. |
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