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Human FAM3D Protein (FAM-HM23D) Summary
Product Description |
Recombinant Human FAM3D Protein is expressed from HEK293 with hFc (IgG1) tag at the C-Terminus.It contains Tyr26-Phe224. |
Product Background |
The physiological homeostasis of gut mucosal barrier is maintained by both genetic and environmental factors and its impairment leads to pathogenesis such as inflammatory bowel disease. A cytokine like molecule, FAM3D (mouse Fam3D), is highly expressed in mouse gastrointestinal tract. Here, we demonstrate that deficiency in Fam3D is associated with impaired integrity of colonic mucosa, increased epithelial hyper-proliferation, reduced anti-microbial peptide production and increased sensitivity to chemically induced colitis associated with high incidence of cancer. |
Product Category |
Recombinant Protein / Antibody discovery / Antibody discovery | Others |
Human FAM3D Protein (FAM-HM23D) Specifications/Details
Protein |
FAM3D |
Synonyms |
EF7; FAM3D; OIT1 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Tyr26-Phe224 |
Molecular Weight |
The protein has a predicted MW of 48.7 kDa. Due to glycosylation, the protein migrates to 55-65 kDa based on Bis-Tris PAGE result. |
Product Tag |
C-hFc (IgG1) |
Fluorophore |
Unconjugated |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
|
|
Human FAM3D on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
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The purity of Human FAM3D is greater than 95% as determined by SEC-HPLC. |
Other Available Proteins:
Finding available proteins...
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