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Human FcRH5/FcRL5 (IRTA2a) Protein (FCR-HM111) Summary
Product Description |
Recombinant Human FcRH5/FcRL5 (IRTA2a) Protein is expressed from HEK293 with His tag at the N-terminus.It contains Gln16-Asn759. |
Product Background |
FcRH5 is a cell surface marker enriched on malignant plasma cells when compared to other hematologic malignancies and normal tissues. DFRF4539A is an anti-FcRH5 antibody-drug conjugated to monomethyl auristatin E (MMAE), a potent anti-mitotic agent. |
Product Category |
Recombinant Protein / Antibody discovery / ADC targets |
Human FcRH5/FcRL5 (IRTA2a) Protein (FCR-HM111) Specifications/Details
Protein |
FcRH5/FcRL5 |
Synonyms |
FcR-like protein 5; FcRH5; FcRL5; BXMAS1; CD307; CD307e; IFGP5; IRTA2; IRTA2a |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Gln16-Asn759 |
Molecular Weight |
The protein has a predicted MW of 82.78 kDa. Due to glycosylation, the protein migrates to 90-120 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Human FcRH5 (IRTA2a), His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-FcRH5 Antibody, hFc Tag with the EC50 of 6.8ng/ml determined by ELISA. |
Product Tag |
N-His |
Fluorophore |
Unconjugated |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 90% as determined by HPLC |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22 um filtered solution in PBS, 8% trehalose (pH 7.4). |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
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Immobilized Human FcRH5 (IRTA2a), His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-FcRH5 Antibody, hFc Tag with the EC50 of 6.8ng/ml determined by ELISA. |
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Human FcRH5 (IRTA2a) on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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The purity of Human FcRH5 (IRTA2a) is greater than 90% as determined by SEC-HPLC. |
Other Available Proteins:
Finding available proteins...
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