Name: Human FGFR2 beta (IIIb) Protein (FGR-HM2BB)
Brand: KactusBio
SKU: FGR-HM2BB-100UG
Price: 345.0 USD
Availability: InStock

Human FGFR2 beta (IIIb) Protein (FGR-HM2BB)

Human FGF10, No Tag immobilized on CM5 Chip can bind Human FGFR2 beta (IIIb), hFc Tag with an affinity constant of 8.43 nM as determined in SPR assay (Biacore T200).

Immobilized Human FGFR2 beta (IIIb) , hFc Tag at 0.5 ug/ml (100 ul/Well) on the plate. Dose response curve for Biotinylated Anti-FGFR2 (IIIb) Antibody, hFc Tag with the EC50 of 19.9 ng/ml determined by ELISA (QC Test).

Immobilized Human FGF-7, No Tag at 5 ug/ml (100 ul/well) on the plate. Dose response curve for Human FGFR2 beta (IIIb), hFc Tag with the EC50 of 0.36 ug/ml determined by ELISA.

Human FGFR2 beta (IIIb) on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%.

The purity of Human FGFR2 beta (IIIb) is greater than 95% as determined by SEC-HPLC.

Express System: HEK293
Product Tag: C-hFc
Purity: >95% as determined by Bis-Tris PAGE;>95% as determined by HPLC
Activity: Immobilized Human FGFR2 beta (IIIb) , hFc Tag at 0.5 ug/ml (100 ul/Well) on the plate. Dose response curve for Biotinylated Anti-FGFR2 (IIIb) Antibody, hFc Tag with the EC50 of 19.9 ng/ml determined by ELISA (QC Test). The affinity constant of 8.43 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Amino Acid Range: Arg152-Glu378

Catalog #FGR-HM2BB

Size

100UG

500UG

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Product Description	Recombinant Human FGFR2 beta (IIIb) Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Arg152-Glu378.
Product Background	Four distinct genes encoding closely related FGF receptors, FGFR1-4, are known. All four genes for FGFRs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid-box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain. Multiple forms of FGFR1-3 are generated by alternative splicing of the mRNAs. A frequent splicing event involving FGFR1 and 2 results in receptors containing all three Ig domains, referred to as the alpha- isoform, or only IgII and IgIII, referred to as the beta isoform.
Product Category	Recombinant Protein / Antibody discovery

Protein	FGFR2 beta (IIIb)
Synonyms	Fibroblast growth factor receptor 2;FGFR-2;KGFR;K-sam;Keratinocyte growth factor receptor;CD332;BEK;KSAM
Accession	P21802-3
Species	Human
Biotinylated	no
Amino Acid Range	Arg152-Glu378
Molecular Weight	The protein has a predicted MW of 52.2 kDa. Due to glycosylation, the protein migrates to 68-75 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Human FGFR2 beta (IIIb) , hFc Tag at 0.5 ug/ml (100 ul/Well) on the plate. Dose response curve for Biotinylated Anti-FGFR2 (IIIb) Antibody, hFc Tag with the EC50 of 19.9 ng/ml determined by ELISA (QC Test). The affinity constant of 8.43 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag	C-hFc
Expression System	HEK293
Purity	>95% as determined by Bis-Tris PAGE;>95% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Human FGF10, No Tag immobilized on CM5 Chip can bind Human FGFR2 beta (IIIb), hFc Tag with an affinity constant of 8.43 nM as determined in SPR assay (Biacore T200).
	Immobilized Human FGFR2 beta (IIIb) , hFc Tag at 0.5 ug/ml (100 ul/Well) on the plate. Dose response curve for Biotinylated Anti-FGFR2 (IIIb) Antibody, hFc Tag with the EC50 of 19.9 ng/ml determined by ELISA (QC Test).
	Immobilized Human FGF-7, No Tag at 5 ug/ml (100 ul/well) on the plate. Dose response curve for Human FGFR2 beta (IIIb), hFc Tag with the EC50 of 0.36 ug/ml determined by ELISA.
	Human FGFR2 beta (IIIb) on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%.
	The purity of Human FGFR2 beta (IIIb) is greater than 95% as determined by SEC-HPLC.