Human FGFR3 beta (IIIb) Protein (FGF-HM4BB)

Express System: HEK293
Product Tag: C-His-Avi
Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Activity: Immobilized Human FGFR3 beta (IIIb) , His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-FGFR3 Antibody, hFc Tag with the EC50 of 10.9ng/ml determined by ELISA. See testing image for detail.
Exact Sequence: Asp127-Gly377

Catalog: FGF-HM4BB

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Product Description	Recombinant Human FGFR3 beta (IIIb) Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Asp127-Gly377.
Product Background	Four distinct genes encoding closely related FGF receptors, FGF R1-4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid‑box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain.FGFR3 is tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts.
Product Category	Recombinant Protein

Target	FGFR3 bata (IIIb)
Synonyms	ACH; CD333; CEK; CEK2; EC 2.7.10; FGF R3; FGFR3; HSFGFR3EX; JTK4
Gene/Protein ID	P22607-2
Species	Human
Exact Sequence	Asp127-Gly377
Molecular Weight	The protein has a predicted MW of 30.5 kDa. Due to glycosylation, the protein migrates to 40-55 kDa based on Tris-Bis PAGE result.
Activity	Immobilized Human FGFR3 beta (IIIb) , His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-FGFR3 Antibody, hFc Tag with the EC50 of 10.9ng/ml determined by ELISA. See testing image for detail.
Product Tag	C-His-Avi
Express System	HEK293
Purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

	Immobilized Human FGFR3 beta (IIIb) , His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-FGFR3 Antibody, hFc Tag with the EC50 of 10.9ng/ml determined by ELISA.
	The purity of Human FGFR3 beta (IIIb) is greater than 95% as determined by SEC-HPLC.
	Human FGFR3 beta (IIIb) on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.