Human FGFR4 Protein (FGF-HM2R4)

  • Express System: HEK293
  • Product Tag: C-hFc
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Activity: The affinity constant of 13.05 nM as determined in SPR assay (Biacore T200). See testing image for detail.
  • Amino Acid Range: Leu22-Asp369

Catalog: FGF-HM2R4

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Product Description Recombinant Human FGFR4 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Leu22-Asp369.

Product Background

Fibroblast growth factor receptor 4 (FGF R4), also known as CD334, is a 110 kDa glycosylated transmembrane receptor tyrosine kinase.Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19.

Product Category

Recombinant Protein

Target

FGFR4
Synonyms CD334; FGF R4; FGFR4; FGFR-4; MGC20292; JTK2; TKF
Accession

Species

Human

Amino Acid Range

Leu22-Asp369
Molecular Weight The protein has a predicted MW of 65.3 kDa. Due to glycosylation, the protein migrates to 80-95 kDa based on Tris-Bis PAGE result.

Activity

The affinity constant of 13.05 nM as determined in SPR assay (Biacore T200). See testing image for detail.

Product Tag

C-hFc

Express System

HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Human FGFR4, hFc Tag captured on CM5 Chip via Protein A can bind Human Beta Klotho, His Tag with an affinity constant of 13.05 nM as determined in SPR assay (Biacore T200).
The purity of-Human FGFR4 is greater than 95% as determined by SEC-HPLC.
Human FGFR4 on Tris-Bis PAGE under reduced conditions. The purity is greater than 95%.

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