Human FGFR4 Protein (FGF-HM4R4)

  • Express System: HEK293
  • Product Tag: C-His-Avi
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Exact Sequence: Leu22-Asp369

Catalog: FGF-HM4R4

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Product Description Recombinant Human FGFR4 Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Leu22-Asp369.

Product Background

Fibroblast growth factor receptor 4 (FGF R4), also known as CD334, is a 110 kDa glycosylated transmembrane receptor tyrosine kinase.Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19.

Product Category

Recombinant Protein

Target

FGFR4
Synonyms CD334; FGF R4; FGFR4; FGFR-4; MGC20292; JTK2; TKF

Gene/Protein ID

P22455-1

Species

Human

Exact Sequence

Leu22-Asp369
Molecular Weight The protein has a predicted MW of 41.4 kDa. Due to glycosylation, the protein migrates to 60-75 kDa based on Tris-Bis PAGE result.

Product Tag

C-His-Avi

Express System

HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
The purity of Human FGFR4 is greater than 95% as determined by SEC-HPLC.
Human FGFR4 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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