Name: Human GARP (Y137H&S138G&G139N) &Latent TGF Beta 1 Complex Protein (GAT-HM405)
Brand: KactusBio
SKU: GAT-HM405-100UG
Price: 450.0 USD
Availability: InStock

Human GARP (Y137H&S138G&G139N) &Latent TGF Beta 1 Complex Protein (GAT-HM405)

Express System: HEK293
Product Tag: C-His-Avi
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Amino Acid Range: His20-Leu628(GARP(Y137H&S138G&G139N)) & Leu30-Ser390(Latent TGF Beta 1)

Catalog #GAT-HM405

Size

100UG

500UG

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Product Description	Recombinant Human GARP(Y137H&S138G&G139N)&Latent TGF Beta 1 Complex Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains His20-Leu628 (GARP(Y137H&S138G&G139N)) & Leu30-Ser390 (Latent TGF beta 1).
Product Background	GARP&Latent TGF Beta is a complex found on surface of many types of cells. In Tregs, GARP is involved in TCR-mediated activation of Latent TGF-β and thus promoting secretion and activation of TGF-β. Integrin αvβ8 on the surface of immune cells and other cells recognizes RGD in LAP, resulting in the release of mature TGF-β from the TGF-β&GARP complex.
Product Category	Recombinant Protein

Target	GARP(Y137H&S138G&G139N)&Latent TGF Beta 1 Complex
Synonyms	LRRC32; GARP; LAP; TGF-beta-1; LRRC32&TGF-beta 1; LRRC32&TGFB1
Accession	Q14392(GARP(Y137H&S138G&G139N))&P01137(Latent TGF beta 1)
Species	Human
Biotinylated	no
Amino Acid Range	His20-Leu628(GARP(Y137H&S138G&G139N)) & Leu30-Ser390(Latent TGF Beta 1)
Molecular Weight	The protein has a predicted MW of 70.3 kDa (GARP(Y137H&S138G&G139N))&41.4 kDa (Latent TGF Beta 1). Due to glycosylation, the protein migrates to 75-80 kDa (GARP(Y137H&S138G&G139N))&15 kDa&43-47 kDa (Latent TGF Beta 1) based on Bis-Tris PAGE result.
Product Tag	C-His-Avi
Express System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

	Human GARP (Y137H&S138G&G139N) &Latent TGF Beta 1 Complex on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Human GARP (Y137H&S138G&G139N) &Latent TGF Beta 1 Complex is greater than 95% as determined by SEC-HPLC.

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