Product Description |
Recombinant Human GCGR/Glucagon receptor Protein-VLP is expressed from HEK293.It contains Met1-Phe477 (It may have cross reaction with anti-His antibody). |
Product Background |
The pancreatic hormone glucagon activates the glucagon receptor (GCGR), a class B seven-transmembrane G protein-coupled receptor that couples to the stimulatory heterotrimeric G protein and provokes PKA-dependent signaling cascades vital to hepatic glucose metabolism and islet insulin secretion. The GCGR expressed at the plasma membrane is constitutively ubiquitinated and upon agonist-activation, internalized GCGRs are deubiquitinated at early endosomes and recycled via Rab4-containing vesicles. |
Product Category |
Recombinant Protein / Antibody discovery / Multiple transmembrane proteins / VLP |
Protein |
GCGR |
Synonyms |
Glucagon receptor; GL-R; GCGR; Glucagon R |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Met1-Phe477 |
Molecular Weight |
The target protein has a predicted MW of 56 kDa. |
Activity |
Immobilized Human GCGR VLP at 5ug/ml (100ul/well) on the plate. Dose response curve for Anti-GCGR Antibody, hFc Tag with the EC50 of 13.1ng/ml determined by ELISA (QC Test). See testing image for detail. |
Expression System |
HEK293 |
Purity |
> 95% as determined by HPLC |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22um filtered solution in PBS, 150mM L-Arginine (pH 7.4). |
Stability And Storage |
Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
|
|
Immobilized Human GCGR VLP at 5ug/ml (100ul/well) on the plate. Dose response curve for Anti-GCGR Antibody, hFc Tag with the EC50 of 13.1ng/ml determined by ELISA (QC Test). |
|
|
The purity of Human GCGR VLP is greater than 95% as determined by SEC-HPLC. |
Related Products
Have more questions?
Check out our Frequently Asked Questions page for more details about product specifications, ordering, and shipments.
Contact Us
More from Antibody Drug Discovery Proteins
Recently viewed
