Human GCGR/Glucagon receptor VLP (GCR-HM00V)

Express System: HEK293
Purity: > 95% as determined by HPLC
Activity: Immobilized Human GCGR VLP at 5ug/ml (100ul/well) on the plate. Dose response curve for Anti-GCGR Antibody, hFc Tag with the EC50 of 8.2ng/ml determined by ELISA.
Recomended Products: VLP Control (VLP-HM00C)
Amino Acid Range: Met1-Phe477

Catalog #GCR-HM00V

Price

$1,235.00

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Human GCGR/Glucagon receptor VLP (GCR-HM00V) Summary

Product Description	Recombinant Human GCGR/Glucagon receptor VLP is expressed from HEK293.It contains Met1-Phe477 (It may have cross reaction with anti-His antibody).
Product Background	The pancreatic hormone glucagon activates the glucagon receptor (GCGR), a class B seven-transmembrane G protein-coupled receptor that couples to the stimulatory heterotrimeric G protein and provokes PKA-dependent signaling cascades vital to hepatic glucose metabolism and islet insulin secretion. The GCGR expressed at the plasma membrane is constitutively ubiquitinated and upon agonist-activation, internalized GCGRs are deubiquitinated at early endosomes and recycled via Rab4-containing vesicles.
Product Category	Recombinant Protein / Antibody discovery / Multiple transmembrane proteins / VLP

Protein	GCGR/Glucagon receptor
Synonyms	Glucagon receptor; GL-R; GCGR; Glucagon R
Accession	P47871
Species	Human
Biotinylated	no
Amino Acid Range	Met1-Phe477
Molecular Weight	The target protein has a predicted MW of 56 kDa.
Activity	Immobilized Human GCGR VLP at 5ug/ml (100ul/well) on the plate. Dose response curve for Anti-GCGR Antibody, hFc Tag with the EC50 of 8.2ng/ml determined by ELISA.
Fluorophore	Unconjugated
Expression System	HEK293
Purity	> 95% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Liquid
Shipping	Shipped with dry ice.
Formulation	Supplied as 0.22um filtered solution in PBS, 300mM L-arginine (pH 7.4). Notice: If you need it for immunization, water-soluble adjuvant is recommended.
Stability And Storage	Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Human GCGR VLP at 5ug/ml (100ul/well) on the plate. Dose response curve for Anti-GCGR Antibody, hFc Tag with the EC50 of 8.2ng/ml determined by ELISA.
	The purity of Human GCGR VLP is greater than 95% as determined by SEC-HPLC.

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