Name: Human GEP Protein (GEP-HM101)
Brand: KactusBio
SKU: GEP-HM101-100UG
Price: 270.0 USD
Availability: InStock

Catalog #GEP-HM101

Size

100UG

500UG

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Product Description	Recombinant Human GEP Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Thr18-Leu593.
Product Background	Haploinsufficiency of progranulin (PGRN) is a leading cause of frontotemporal lobar degeneration (FTLD). Loss of PGRN leads to lysosome dysfunction during aging. TMEM106B, a gene encoding a lysosomal membrane protein, is the main risk factor for FTLD with PGRN haploinsufficiency.Loss of both PGRN and TMEM106B results in an increased accumulation of lysosomal vacuoles in the axon initial segment of motor neurons and enhances the manifestation of FTLD phenotypes with a much earlier onset.
Product Category	Recombinant Protein / Antibody discovery

Protein	GEP
Synonyms	Progranulin; PGRN; Acrogranin; GP88; Glycoprotein 88; PCDGF; PEPI; CLN11; GEP; Granulin; GRN
Accession	P28799-1
Species	Human
Biotinylated	no
Amino Acid Range	Thr18-Leu593
Molecular Weight	The protein has a predicted MW of 62.9 kDa. Due to glycosylation, the protein migrates to 75-82 kDa based on Bis-Tris PAGE result.
Product Tag	C-His
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Human GEP on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Human GEP is greater than 95% as determined by SEC-HPLC.