Product Description |
Recombinant Human GEP Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Thr18-Leu593. |
Product Background |
Haploinsufficiency of progranulin (PGRN) is a leading cause of frontotemporal lobar degeneration (FTLD). Loss of PGRN leads to lysosome dysfunction during aging. TMEM106B, a gene encoding a lysosomal membrane protein, is the main risk factor for FTLD with PGRN haploinsufficiency.Loss of both PGRN and TMEM106B results in an increased accumulation of lysosomal vacuoles in the axon initial segment of motor neurons and enhances the manifestation of FTLD phenotypes with a much earlier onset. |
Product Category |
Recombinant Protein |
Target |
GEP |
Synonyms |
Progranulin; PGRN; Acrogranin; GP88; Glycoprotein 88; PCDGF; PEPI; CLN11; GEP; Granulin; GRN |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Thr18-Leu593 |
Molecular Weight |
The protein has a predicted MW of 62.9 kDa. Due to glycosylation, the protein migrates to 75-82 kDa based on Bis-Tris PAGE result. |
Product Tag |
C-His |
Express System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
|
|
Human GEP on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
|
The purity of Human GEP is greater than 95% as determined by SEC-HPLC. |
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