Human GITR/TNFRSF18 Protein (GTR-HM201)
Catalog: GTR-HM201
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Product Description | Recombinant Human GITR/TNFRSF18 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Gln26-Glu161. |
Product Background |
GITR (glucocorticoid-induced tumor necrosis factor receptor), also known as AITR and TNFRSF18, is a 40 kDa transmembrane glycoprotein that functions in immune regulation.GIRT is a receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway. |
Product Category |
Recombinant Protein |
Target |
GITR/TNFRSF18 |
Synonyms | CD357; GITR; GITR-D; TNFRSF18; AITR |
Gene/Protein ID |
Q9Y5U5-1 |
Species |
Human |
Exact Sequence |
Gln26-Glu161 |
Molecular Weight | The protein has a predicted MW of 41.3 kDa. Due to glycosylation, the protein migrates to 45-55 kDa based on Tris-Bis PAGE result. |
Activity |
Immobilized Human GITR Ligand Trimer, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Human GITR, hFc Tag with the EC50 of 0.44ug/ml determined by ELISA. See testing image for detail. |
Product Tag |
C-hFc |
Express System |
HEK293 |
Purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
Endotoxin | Less than 1EU per ug by the LAL method. |
Form | Lyophilized |
Shipping | Shipped at ambient temperature. |
Formulation | Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage | Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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