• Express System: HEK293
  • Purity: > 95% as determined by HPLC
  • Activity: Immobilized Human GPR146 VLP at at 5ug/ml (100ul/well) on the plate. Dose response curve for Anti-GPR146 Antibody, Rabbit IgG Tag with the EC50 of 1.42ug/ml determined by ELISA.
  • Amino Acid Range: Met1-Ala333
Catalog #GPR-HM046
Price
Regular price $1,23500
Regular price Sale price $1,23500
/
Size
Avantor VWR Fisher Scientific

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Human GPR146 VLP (GPR-HM046) Summary

Product Description

 Recombinant Human GPR146 VLP is expressed from HEK293.It contains Met1-Ala333 (It may have cross reaction with anti-His antibody).

Product Background

 Orphan G protein-coupled receptor 146 (GPR146), a susceptible gene associated with plasma total cholesterol (TC), LDL-C and high density lipoprotein cholesterol (HDL-C) levels, in regulation of systemic cholesterol metabolism. GPR146 promotes activity of hepatic sterol regulatory element binding protein 2 (SREBP2) through activation of the extracellular signal-regulated kinase (ERK) signaling pathway, thereby regulating hepatic very low-density lipoprotein (VLDL) secretion, and subsequently circulating low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG) levels.

Human GPR146 VLP (GPR-HM046) Specifications/Details

Protein
 GPR146
Synonyms
 PGR8; G protein-coupled receptor 146
Accession
Species
 Human
Biotinylated
 no
Amino Acid Range
 Met1-Ala333
Molecular Weight
 The target protein has a predicted MW of 39.79 kDa.
Activity
 Immobilized Human GPR146 VLP at at 5ug/ml (100ul/well) on the plate. Dose response curve for Anti-GPR146 Antibody, Rabbit IgG Tag with the EC50 of 1.42ug/ml determined by ELISA.
Fluorophore
 Unconjugated
Expression System
 HEK293
Purity
 > 95% as determined by HPLC
Endotoxin
 Less than 1 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form
 Liquid
Shipping
 Shipped with dry ice.
Formulation
 Supplied as 0.22 um filtered solution in PBS, 300mM L-Arginine (pH 7.4). Notice: If you need it for immunization, water-soluble adjuvant is recommended.
Stability And Storage
 Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

Immobilized Human GPR146 VLP at at 5ug/ml (100ul/well) on the plate. Dose response curve for Anti-GPR146 Antibody, Rabbit IgG Tag with the EC50 of 1.42ug/ml determined by ELISA. Immobilized Human GPR146 VLP at at 5ug/ml (100ul/well) on the plate. Dose response curve for Anti-GPR146 Antibody, Rabbit IgG Tag with the EC50 of 1.42ug/ml determined by ELISA.
The purity of Human GPR146 VLP is greater than 95% as determined by SEC-HPLC. The purity of Human GPR146 VLP is greater than 95% as determined by SEC-HPLC.
Other Available Proteins:
Finding available proteins...