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Human GPR146 VLP (GPR-HM046) Summary
Product Description |
Recombinant Human GPR146 VLP is expressed from HEK293.It contains Met1-Ala333 (It may have cross reaction with anti-His antibody). |
Product Background |
Orphan G protein-coupled receptor 146 (GPR146), a susceptible gene associated with plasma total cholesterol (TC), LDL-C and high density lipoprotein cholesterol (HDL-C) levels, in regulation of systemic cholesterol metabolism. GPR146 promotes activity of hepatic sterol regulatory element binding protein 2 (SREBP2) through activation of the extracellular signal-regulated kinase (ERK) signaling pathway, thereby regulating hepatic very low-density lipoprotein (VLDL) secretion, and subsequently circulating low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG) levels. |
Product Category |
Recombinant Protein / Antibody discovery / Multiple transmembrane proteins / VLP |
Human GPR146 VLP (GPR-HM046) Specifications/Details
Protein |
GPR146 |
Synonyms |
PGR8; G protein-coupled receptor 146 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Met1-Ala333 |
Molecular Weight |
The target protein has a predicted MW of 39.79 kDa. |
Activity |
Immobilized Human GPR146 VLP at at 5ug/ml (100ul/well) on the plate. Dose response curve for Anti-GPR146 Antibody, Rabbit IgG Tag with the EC50 of 1.42ug/ml determined by ELISA. |
Fluorophore |
Unconjugated |
Expression System |
HEK293 |
Purity |
> 95% as determined by HPLC |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22 um filtered solution in PBS, 300mM L-Arginine (pH 7.4). |
Stability And Storage |
Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
|
|
Immobilized Human GPR146 VLP at at 5ug/ml (100ul/well) on the plate. Dose response curve for Anti-GPR146 Antibody, Rabbit IgG Tag with the EC50 of 1.42ug/ml determined by ELISA. |
|
|
The purity of Human GPR146 VLP is greater than 95% as determined by SEC-HPLC. |
Other Available Proteins:
Finding available proteins...
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