Name: Human GPRC5D Nanodisc (GPR-HM15P)
Brand: KactusBio
SKU: GPR-HM15P-100UG
Price: 1210.0 USD
Availability: InStock

Express System: HEK293
Product Tag: C-His
Activity: Immobilized Human GPRC5D Nanodisc, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-GPRC5D Antibody, hFc Tag with the EC50 of 5.8ng/ml determined by ELISA. The affinity constant of 1.47 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Amino Acid Range: Met1-Val345

Catalog #GPR-HM15P

Size

100UG

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Human GPRC5D Nanodisc (GPR-HM15P) Summary

Product Description	Recombinant Human GPRC5D Nanodisc is expressed from HEK293 with His tag at the C-terminus.It contains Met1-Val345.
Product Background	Chimeric antigen receptor (CAR) T cells, a type of cell-based immunotherapy, have shown some promising results in multiple myeloma, a bone marrow cancer.The orphan G protein–coupled receptor, class C group 5 member D (GPRC5D), normally expressed only in the hair follicle, Using quantitative immunofluorescence, we determined that GPRC5D protein is expressed on CD138 MM cells from primary marrow samples with a distribution that was similar to, but independent of, BCMA.
Product Category	Recombinant Protein / Antibody discovery / Multiple transmembrane proteins / Nanodisc

Human GPRC5D Nanodisc (GPR-HM15P) Specifications/Details

Protein	GPRC5D
Synonyms	GPRC5D; MGC129713; MGC129714; orphan G-protein coupled receptor
Accession	Q9NZD1-1
Species	Human
Biotinylated	no
Amino Acid Range	Met1-Val345
Molecular Weight	The protein has a predicted MW of 39.6 kDa.
Activity	Immobilized Human GPRC5D Nanodisc, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-GPRC5D Antibody, hFc Tag with the EC50 of 5.8ng/ml determined by ELISA. The affinity constant of 1.47 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag	C-His
Expression System	HEK293
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Liquid
Shipping	Shipped with dry ice.
Formulation	Supplied as 0.22 um filtered solution in PBS, 200mM L-Arginine (pH 7.4). Notice: Not recommended for flow cytometry in mammalian cells.
Stability And Storage	Valid for 6 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Human GPRC5D Nanodisc, His Tag captured on CM5 Chip via anti-his antibody can bind Anti-GPRC5D Antibody with an affinity constant of 1.47 nM as determined in SPR assay (Biacore T200).
	Immobilized Human GPRC5D Nanodisc, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-GPRC5D Antibody, hFc Tag with the EC50 of 5.8ng/ml determined by ELISA.