Human GPRC5D Protein-Nanodisc (GPR-HM15P)
  • Express System: HEK293
  • Product Tag: C-His
  • Activity: Immobilized Human GPRC5D Nanodisc, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Anti-GPRC5D Antibody, hFc Tag with the EC50 of 4.9ng/ml determined by ELISA (QC Test). The affinity constant of 1.47 nM as determined in SPR assay (Biacore T200). See testing image for detail.
  • Amino Acid Range: Met1-Val345
Catalog #GPR-HM15P
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Product Description
 Recombinant Human GPRC5D Protein-Nanodisc is expressed from HEK293 with His tag at the C-terminus.It contains Met1-Val345.
Product Background
 Chimeric antigen receptor (CAR) T cells, a type of cell-based immunotherapy, have shown some promising results in multiple myeloma, a bone marrow cancer.The orphan G protein–coupled receptor, class C group 5 member D (GPRC5D), normally expressed only in the hair follicle, Using quantitative immunofluorescence, we determined that GPRC5D protein is expressed on CD138 MM cells from primary marrow samples with a distribution that was similar to, but independent of, BCMA.
Product Category
 Recombinant Protein
Target
 GPRC5D
Accession
Species
 Human
Biotinylated
 no
Amino Acid Range
 Met1-Val345
Molecular Weight
 The protein has a predicted MW of 42.10 kDa.
Activity
 Immobilized Human GPRC5D Nanodisc, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Anti-GPRC5D Antibody, hFc Tag with the EC50 of 4.9ng/ml determined by ELISA (QC Test). The affinity constant of 1.47 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag
 C-His
Express System
 HEK293
Endotoxin
 Less than 1EU per ug by the LAL method.
Form
 Liquid
Shipping
 Shipped with dry ice.
Formulation
 Supplied as 0.22 um filtered solution in PBS (pH 7.4). Notice: Not recommended for immunization.
Stability And Storage
 Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Human GPRC5D Nanodisc, His Tag captured on CM5 Chip via anti-his antibody can bind Anti-GPRC5D Antibody with an affinity constant of 1.47 nM as determined in SPR assay (Biacore T200).
Immobilized Human GPRC5D Nanodisc, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Anti-GPRC5D Antibody, hFc Tag with the EC50 of 4.9ng/ml determined by ELISA (QC Test).

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