• Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Activity: Immobilized Human GUCY2C, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Anti-GUCY2C Antibody, hFc Tag with the EC50 of 11.5ng/ml determined by ELISA.
  • Amino Acid Range: Ser24-Gln430
Catalog #GCC-HM101
Price
Regular price $31500
Regular price Sale price $31500
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Size
Avantor VWR Fisher Scientific

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Human GUCY2C/Guanylyl cyclase C Protein (GCC-HM101) Summary

Product Description

 Recombinant Human GUCY2C/Guanylyl cyclase C Protein is expressed from HEK293 with His tag at the C-terminus.It contains Ser24-Gln430.

Product Background

 Guanylyl cyclase C (GUCY2C) has canonical centrality in defense of key intestinal homeostatic mechanisms, encompassing fluid and electrolyte balance, epithelial dynamics, antitumorigenesis, and intestinal barrier function. GUCY2C may represent a new target for anti-obesity pharmacotherapy.

Human GUCY2C/Guanylyl cyclase C Protein (GCC-HM101) Specifications/Details

Protein
 GUCY2C/Guanylyl cyclase C
Synonyms
 Guanylyl cyclase C; GC-C; STAR; GUCY2C; GUC2C; STA receptor; DIAR6; EC 4.6.1; GCC; GUC2CEC 4.6.1.2; MUCIL;EC4.6.1; GUC2CEC4.6.1.2
Accession
Species
 Human
Biotinylated
 no
Amino Acid Range
 Ser24-Gln430
Molecular Weight
 The protein has a predicted MW of 47.62 kDa. Due to glycosylation, the protein migrates to 70-90 kDa based on Bis-Tris PAGE result.
Activity
 Immobilized Human GUCY2C, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Anti-GUCY2C Antibody, hFc Tag with the EC50 of 11.5ng/ml determined by ELISA.
Product Tag
 C-His
Fluorophore
 Unconjugated
Expression System
 HEK293
Purity
 > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin
 Less than 0.1 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form
 Liquid
Shipping
 Shipped with dry ice.
Formulation
 Supplied as 0.22 um filtered solution in PBS (pH 7.4).
Stability And Storage
 Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

Immobilized Human GUCY2C, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Anti-GUCY2C Antibody, hFc Tag with the EC50 of 11.5ng/ml determined by ELISA. Immobilized Human GUCY2C, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Anti-GUCY2C Antibody, hFc Tag with the EC50 of 11.5ng/ml determined by ELISA.
Human GUCY2C on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. Human GUCY2C on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human GUCY2C is greater than 95% as determined by SEC-HPLC. The purity of Human GUCY2C is greater than 95% as determined by SEC-HPLC.
Other Available Proteins:
Finding available proteins...